Sarms

MK-2866/Ostarine CAS:1202044-20-9、841205-47-8
LGD-4033 CAS:1165910-22-4
GW-501516/Cardarine CAS:317318-70-0
MK-677 CAS:159752-10-0
GTX-007/S4/Andarine CAS:401900-40-1
SR-9009 CAS:1379686-30-2
SR-9011 CAS : 1379686-29-9
RAD-140 CAS:118237-47-0
YK-11 CAS:431579-34-9
GW-0742 CAS:317318-84-6
AICAR CAS:2627-69-2
GS5816 CAS:1377049-84-7
Sunifiram CAS: 314728-85-3
RU 58841 CAS : 154992-24-2

 

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Tadanafil

White Tadanafil Natural Sex Steroid Hormones CAS 171596-29-5 Cialis

 

Quick Details for Tadalafil Cialis

Product Name: Tadalafil
Synonyms: TADALAFIL;CIALIS;IC 351;(6r,12ar)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione;TADALAFIL(CIALIS);Taladafil (cialis);Cialis/taladafil;Cialis(IC351)
CAS: 171596-29-5
MF: C22H19N3O4
MW: 389.4
EINECS: 200-835-2
Product Categories: Active Pharmaceutical Ingredients;Cnbio;Erectile Dysfunction;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API’s;Steroid and Hormone;Inhibitor;API;Tadalafil;NUCYNTA;Pyridines ,Halogenated Heterocycles
Melting point : 298-300°C
Chemical Properties : White to Off-White Cyrstalline Solid
Usage : Used for the treatment of erectile dysfunction. A phosphodiesterase 5 inhibitor .
Usage : analgesic, norepinephrine uptake blocker, mu-opiod receptor agonist .

 

Tadalafil Description

1. Tadalafil (Tadalifil citrate), a phosphodiesterase type 5 inhibitor, is used to treat erectile dysfunction (ED) and decreased libido in males.

2. Tadalafil works by aiding relaxation of blood vessels and increasing blood flow in the penis during sexual arousal, resulting in improved erectile function. Tadalafil is much longer lasting. Effects can be felt anywhere between 36-48 hours.

3. Action: Tadalafil improves erectile function significantly, possibly increased sexual activity, and is very safe.

4. There are limited side effects associated with its use. The most common side effects are headache, upset stomach, back pain, and muscle aches, and usually subside with in a few hours.

Tadalafil was also found to be significantly higher at the end of the month, due to increased sexual activity.

 

Tadalafil Applications

1. Tadalafil is a PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Tadalafil, and under the name Adcirca for the treatment of pulmonary arterial hypertension.

2. Tadalafil’s pharmacologic distinction is its longer half-life (17.50 hours) resulting in longer duration of action, and so partly responsible for “The Weekend Pill” sobriquet. Furthermore, the longer half-life is the basis for current investigation of tadalafil’s daily therapeutic use in relieving pulmonary arterial hypertension .

 

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AICAR

AMPK Activator SARM Steroids AICAR Acadesine CAS 2627-69-2 Nucleoside Analogue Powder

 

Aicar Quick View

AICA-Ribonucleotide (AICAR), also known as ZMP, is an analog of AMP that is capable of stimulating AMP-dependent protein kinase activity (AMPK). AICAR is being researched to treat and protect against cardiac ischemic injury. If left untreated, it may lead to a myocardial infarct. Cardiac Ischemia is caused by insufficient blood flow and oxygen to the myocardium. AICAR was first used in the 1980s as a method to preserve blood flow to the heart during surgery.

 

Quick Details for Aicar

Product Name : Aicar
Alias : Acadesine; 5-Aminoimidazole-4-carboxamide ribonucleoside; 5-Aminoimidazole-4-carboxamide riboside; AICA-riboside; AIC-Riboside;
Assay : 98%
MF : C9H14N4O5
MW : 258.2313
Appearance : White Lyophilized powder
Type : Vitamins, Amino Acids and Coenzymes
Usage : For cardioprotective use . Aicar further works at the cellur and metabolic level to achieve increased muscle enduance.

 

Aicar Descriptions

AICAR is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide.

It can also be known as AICA ribonucleotide, ZMP, or Acadesine. It is an intermediate contained in the generation of inosine monophosphate. It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production. It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.

AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).

AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide’s presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.

 

Aicar Application

Glucose uptake stimulant; AMPK activator.AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) hav e been recognized for therapeutic potential in myocardial ischemia. Cardioprotective.

Biological Activity Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

AICAR is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide. It can also be known as AICA ribonucleotide, ZMP, or Acadesine. It is an intermediate contained in the generation of inosine monophosphate. It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production. It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.

 

Aicar Function

AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).

AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide’s presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.

 

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GW0742

Highly Selective GW0742 99% Natural Nutrition Supplements CAS 317318-84-6

 

Quick Details for GW0742

Product Name: GW0742
Synonyms: GW0742;[4-[[[2-[3-FLUORO-4-(TRIFLUOROMETHYL)PHENYL]-4-METHYL-5-THIAZOLYL]METHYL]THIO]-2-METHYLPHENOXY]ACETIC ACID;4-[2-(3-FLUORO-4-TRIFLUOROMETHYL-PHENYL)-4-METHYL-THIAZOL-5-YLMETHYLSULFANYL]-2-METHYL-PHENOXY-ACETIC ACID;4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]AceticAcid;4-[2-(3-Fluoro-4-trifluoromethyl-phenyl)-4-methyl-thiazol-5-ylmethylsulfanyl]- 2-methyl-phenoxy}-acetic acid;Acetic acid, 2-[4-[[[2-[3-fluoro-4-(trifluoroMethyl)phenyl]-4-Methyl-5-thiazolyl]Methyl]thio]-2-Methylphenoxy]-;2-(4-(((2-(3-Fluoro-4-(trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methyl)thio)-2-methylphenoxy);GW 0742X
CAS: 317318-84-6
MF: C21H17F4NO3S2
MW: 471.49
Product Categories: All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Inhibitor
Melting point : 134.5-135.5 °C
Storage temp. : 2-8°C
Chemical Properties : White Solid
Usage : A small molecule agonist of the human Peroxisome Proliferator-Activated Recept d (PPAR d). It shows an EC50 of 1.1 nM against PPAR d with 100-fold selectivity over the other human subtypes
Usage : A small molecule agonist of the human Peroxisome Proliferator-Activated Recept δ (PPAR δ). It shows an EC50 of 1.1 nM against PPAR δ with 100-fold selectivity over the other human subtypes.

 

GW0742 Description

GW0742 shows activity aganist hPPARα, hPPARγ and hPPARδ with EC50 of 1.1 μM, 2 μM and 1 nM, respectively, in cell based transactivation assay. GW0742 (0.2 μM and 1 μM) significant increases in reporter activity of PPARβ/δ in N/TERT-1 keratinocytes. GW0742 (1 μM) results in significant inhibition in the average number of N/TERT-1 keratinocytes. GW0742 (1 μM) results in an increase in the number of cells in the G1 phase and a decrease in the number of cells in the S phase. GW0742 (1 μM) causes a significant increase in the mRNA encoding ADRP, a known PPARβ/δ target gene, in N/TERT-1 keratinocytes as well as mouse primary keratinocytes. GW0742 (1 μM) results in significantly reduced phosphorylation of retinoblastoma (Rb) and a significantly lower level of p42/44 ERK in N/TERT-1 cells. GW0742 (1 μM) leads to an increase in the mRNA encoding a number of known markers of terminal differentiation including TG-I, SPR1A, K10 and involucrin. GW0742 at 100 μM produces a significant reduction in low-KCl-induced neuronal cell death in cerebellar granule neurons. GW0742 at 100 μM induces a pronounced increase in cell death as measured by LDH release after 48 hr of incubation. GW0742 at 100 μM produces a pronounced increase in c-Jun expression at 6 hours in cerebellar granule neuron cultures. GW0742 at 100 μM increases PPARα-mediated transactivation dependent on the presence of 1.5% BSA in MCF-7 cells .

 

How it works ?

ENDUROBOL is a selective agonist ( activator ) of the PPARδ receptor . It displays high affinity ( Ki = 1 nM ) and potency ( EC50 = 1 nM ) for PPARδ with > 1000 fold selectivity over PPARα and PPARγ .

It activates AMP-activated protein kinase and stimulates glucose uptake in skeletal muscle tissue , and GW 501516 has been demonstrated to reverse metabolic abnormalities in obese men with pre-diabetic metabolic syndrome , most likely by stimulating fatty acid oxidation . It has been proposed as a potential treatment for obesity and related conditions , especially when used in conjunction with a synergistic compound AICAR , as the combination has been shown to significantly increase exercise endurance in human .

GW0742 is a synthetic, potent and selective PPAR-β/δ agonist. PPARs are ligand-dependent transcription factors which are involved in many physiological processes, such as inflammation and energy homeostasis. PPAR-β/δ is one of three PPARs in the nuclear hormone receptor superfamily that are collectively involved in the control of lipid homoeostasis among other functions. GW0742 can attenuate the increase of PARP activity that caused by SAO shock. GW0742 is also able to prevent radiation-induced brain injury in C57Bl/6 wild-type (WT) and PPARδ knockout (KO) mice. Dietary GW0742 can prevent the acute increase in IL-1β mRNA and ERK phosphorylation measured at 3 h after a single 10-Gy dose of WBI as well as the increase in the number of activated hippocampal microglia 1 week after WBI .

 

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YK11

YK11 Powder Sarms Muscle Strength Steroid YK-11 431579-34-9 YK11 For Fitness Supplement

 

Quick Details for YK11

Product name : YK11
CAS: 431579-34-9
Assay: 99.5%
Appearance: white powder
Dosage: Daily dosage of YK11 is 4mg/day for hardcore users max 8mg/day
Melting Point : 125ºC-127ºC
Specific Rotation : +27.5°
Loss On Drying : 0.20%
Residue On Ignition : 0.02%

 

YK-11 offers the extreme muscle building properties of steroids without the nasty steroid side effects and is a fantastic solution for those who don’t like to use steroids.

 

YK11 Benefits

YK-11 induces muscle cells to make more follistatin which is a strong myostatin inhibitor. Myostatin (also known as growth differentiation factor 8) as a myokine, a protein produced by muscle cells that acts on muscle cells to inhibit myogenesis.

Myogenesis is muscle cell growth and differentiation. Research through the years show that when you block myostatin, it allows for significantly more muscle mass.

In addition to that, YK-11 is a bit leaner than LGD-4033, and is excellent for lean gains on par with testosterone. It produces lean, dry, easily kept gains in strength and muscle, and reductions in bodyfat.

YK-11 selectively binds to the androgen receptors similarly to LGD-4033, and MK-2866. That is to say, that YK-11 offers great promise as therapy for muscle wasting illnesses, and for promoting very massive muscle gains. Much like MK-2866, and LGD-4033, YK-11 binds to the androgen receptors in muscle, and bone. YK-11 is weakly anabolic to androgenic ratio of greater than 25:1. This means that YK-11 is very weakly androgenic, and provides anabolic effects while minimizing the negative effects on the prostate and other organs. YK-11 appears to be weakly suppressive to the Hypothalamic Pituitary Testicular Axis (HPTA), but far less so than any anabolic steroids or prohormones. YK-11 users have observed no elevations in estrogen, and decreases sex hormone binding globulin (which would result in a raised free testosterone, but not total testosterone). In addition to that, YK-11 is a bit leaner than LGD-4033, and is excellent for lean gains on par with testosterone. It produces lean, dry, easily kept gains in strength and muscle, and reductions in bodyfat.

like anabolic steroids, some SARMs are far more effective than others. YK11 is one of the newest SARMs on the market – definitely fits into the upper-echelon of these compounds. In fact, YK11 has been proven to change your genetic potential for building muscle! This being said, let’s discuss how YK11 accomplishes this as well as why it might be the most powerful SARM available.

 

How YK11 works ?

YK11 attaches itself to the AR (androgen receptor), but only inducts methods that lead to the traditional side effects of androgens such as growth of body hair and prostate and enhanced aggression – to a restricted degree.

Most SARMS have quite limited androgenic side effects, but frequently only quite few anabolic effects when likened to testosterone.

YK11 induces muscle cells to make more follistatin (more than DHT does) – a strong myostatin inhibitor. YK11 works through the androgen receptor.

With that said, YK11 can be as good as testosterone in terms of muscle strengthening, but minus the detrimental side effects.

 

YK11 Usage and Benefits

1) Muscle Strength: While the research chemical is are latively new discovery, it does not come short but actually generous of muscle strengthening benefits for users. As indicated in the report of Kanno, muscle cells exposed to it creates more anabolic effects than those exposed with DHT.

On that note, it can be safe to say that it is best for muscle strengthening,without the detrimental effects caused by traditional steroids,including many health risks. What takes place is that it induces muscle cells, stimulating them to create a greater number of follistatin, much better than DHT.

Benefits: it cannot be ignored that this research chemical, being a SARM works through the muscle’s androgen receptors but does not harm the bones and joints and other body parts where ARs are found-due to its SELECTIVE ACTIVITY.

2) Myostat Ininhibitor: While YK-11 has been proven to work as a great supplement for building muscle strength, especially ideal for bodybuilders and athletes, it is also found to be a great myostatin inhibitor. It is special and valuable as a SARM that acts as a strong androgen but without the side effects you will commonly experience from injectable alternatives, like steroids and prohormones.

Benefits: It also works as a myostatin inhibitor. What is myostatin, anyway? This is a type of protein that limits the production and the growth of the muscle tissues, when it is present. So by inhibiting myostatin action, you can actually improve your body’s potential to build bigger and leaner muscle tissue. But while it sounds too good to be true, it has been proven by the scientists themselves.

What happens is that it also inhibits the production and gradually deactivates follistatin, a myostatin inhibitor. On that note, it can be told that it is a potent and effective myostatin inhibitor aside from its anabolic properties, which means more muscle for you!

3) Muscle Growth: So if you’re looking to experience excellent bodybuilding results, you may want to consider this research chemical, which can be taken at doses between 5 and 8 mg per day at an eight-week cycle. However, you may be concerned about estrogen effects, including breast enlargements, but that’s now out of the picture.

Benefits: Because of its selective characteristic, it does what it does very well but only on the anabolic activity of the muscle cells for muscle growth without the adverse estrogen effects, which may cause you humiliation for sporting ‘man boobs.’

Additionally,this compound does not alter the expression of other genes in the body because it leaves out the androgen receptors in other body parts, including the bones, joints and prostate. Therefore, you can experience great muscle building benefits, except the side effects you might have to face if you would choose typical steroids on the market.

The best part is that it delivers all the above-mentioned benefits without harming your body, especially your liver-something that you might have to deal with by choosing other prohormones on the market, which may require longer use before any dramatic results can be achieved.

 

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RAD-140

Testolone Selective Androgen Receptor Modulators SARMs Steroids Muscle Building RAD140 CAS 1182367-47-0

 

Quick Details for RAD-140

Product name : Testolone RAD-140
CAS No. : 1182367-47-0
Molecular Formula : C20H16ClN5O2
Molecular Weight : 393.83
Purity : 99%
Appearance : White Powder
Grade : Pharmaceutical Grade
Usage : SARMs(Selective androgen receptor modulator) .

 

RAD140(Testolone) is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting,it has similar effects to those of anabolic steroids, but without the harsh side effects because it acts on the androgen receptors in a selective manner.

 

Who need Testolone (RAD140)

1.Those who have low testosterone because of health issues, or prior abuse of anabolic steroids.

2.Bodybuilders who want to bridge between steroid cycles. Imagine being able to use testosterone in between your existing anabolic steroid cycles without worrying about suppression and damaging your HPTA. This will allow you to keep more strength and muscle off cycle then you ever have before.

3.Those who want to use a performance enhancing drug, but are concerned with the possible side effects. In such situation, one could cycle RAD140 instead of anabolic steroids and not worry about shutdown or the negative health effects caused by steroids.

4.Those sensitive to gynecomastia. RAD140 is like using testosterone, but without the risk of estrogenic side effects because it does not aromatize into estrogen. Therefore, if a testosterone base is needed during a cycle, RAD140 can be used without fear of getting bitch tits or bloating.

 

Benefits of RAD140

Akin to having an anabolic steroid and prohormone cycle, you’re going to have the following benefits when you use RAD 140 SARM :

1.Enhanced speed, stamina and endurance during high-intensity workouts

2.Faster buildup of muscular tissues that helps you achieve more gains in a shorter period of time .

3.Based on medical tests, RAD 140 SARM also displayed a greater anabolic effect than testosterone when used. Researchers pointed out that besides having a more “reinforced” effect than testosterone, RAD 140 SARM was also seen to help reduce the androgenic side effects that can be potentially caused by the same on the prostate.

This makes its usage way safer and more effective compared to traditional prohormones and anabolic steroids available commercially.

 

RAD140 Dosage

RAD140 can be dosed at 20-30 milligrams (mg) per day, and thanks to a relatively long half life, you can get away with only once a day dosing schedule. Regarding the possible cycle durations, RAD140’s length of use can vary from 6 to 12 weeks. Since it usually comes in liquid form, this SARM is squirted into the mouth, swallowed, and chased down with juice. There is no need to let it sit in the mouth or under tongue; in fact, sublingual use is highly discouraged .

 

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SR9009

Sarms Stenabolic Sr9009 for Sarcopenia Treatment CAS 1379686-30-2

 

Quick Details for SR9009

Product Name : SR9009
Synonyms : SR9009, sr-9009
CAS No. : 1379686-30-2
MF : C20H24ClN3O4S
MW : 3367.2
Purity : 99%
Appearance : White powder
Grade : Pharmaceutical Grade
SR-9009 Product Categories: SARMs(Selective androgen receptor modulator)

 

SR-9009 Description

Stenabolic has the ability to alter the activity of the skeletal muscle mitochondria, or in simple terms – it boosts your metabolic activity. This makes it similar to what DNP does, being SR9009 much safer and not counter productive to your endurance goals. What’s more, unlike DNP, SR9009 has the ability to mimic actual aerobic exercise without actually putting in the conditioning. Therefore, it will boost your endurance instead of hurting it.

This is important, as this protein influences fat and sugar burning in the liver, production of fat cells, and the body’s inflammatory responses. As a result, this interaction between SR9009 and Rev-erbA allows you to make your current exercise regiment much more effective. In fact, even sitting on your butt all day will not hinder your objectives. All in all, the ultimate goal is to burn off for energy from what you eat, instead of getting it stored as fat, which SR does great. Furthermore, it will attack the existing fat and burn it off.

 

SR-9009 Dosage

Stenabolic should be dosed at 20-30 mg per day and adjusted up or down by 10mg depending on user preference. Regarding the cycle duration, the typical cycle length is 6-8 weeks, and it would be wise to stack SR9009 with Cardarine (GW-501516) for a double dose of endurance power.

There is a big inconvenience with Stenabolic when compared to Cardarine, SR9009 does not have a long half life, so it is must be dosed 3-4 times per day. However, some have had good success dosing it at 2-3 times per day .

 

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