Local Anesthetics

Benzocaine CAS:94-09-7
Benzocaine hydrochloride CAS:23239-88-5
Tetracaine hydrochloride CAS:136-47-0
Procaine CAS:59-46-1
Tetracaine CAS:94-24-6
Pramoxine Hydrochloride CAS:637-58-1
Procaine HCl CAS:51-05-8
Lidocaine CAS:137-58-6
Dibucaine hydrochloride CAS:61-12-1
Cinchocaine CAS:85-79-0
Prilocaine CAS:721-50-6
Propitocaine hydrochloride CAS:1786-81-8
Proparacaine hydrochloride CAS:5875-06-9
Lidocaine hydrochloride CAS:73-78-9
Articaine hydrochloride CAS:23964-57-0
Levobupivacaine hydrochloride CAS:27262-48-2
Ropivacaine hydrochloride CAS:132112-35-7
Bupivacaine CAS:2180-92-9
Bupivacaine hydrochloride CAS:14252-80-3
Mepivacaine hydrochloride CAS: 1722-62-9
DIOXOPROMETHAZINE HCL CAS: 13754-56-8
Dimethocaine / Larocaine CAS: 94-15-5

 

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Bupivacaine Hydrochloride

Local Anesthetic Agents Bupivacaine Hydrochloride 14252-80-3 Bupivacaine

 

Quick Details of Bupivacaine hydrochloride

Product name : Bupivacaine hydrochloride
Alias : Bupivocoine HCl; Marcaina; BUPIVACAINE HYDROCHLORIDE ANHYDROUS
CAS: 14252-80-3
EINECS number: 241-917-8
Molecular formula: C18H31ClN2O2
Molecular Weight: 342.9039
Boiling point: 423.4 ° C at 760 mmHg
Flash Point: 209.9 ° C
Vapor Pressure: 2.24E-07mmHg at 25 ° C
Product use: After local anesthesia for surgery and postoperative analges

 

Bupivacaine hydrochloride Description

Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease feeling in a specific area.It is used by injecting it into the area, around a nerve that supplies the area, or into the spinal canal’s epidural space. It is available mixed with a small amount of epinephrine to make it last longer. It typically begins working within 15 minutes and lasts for 2 to 8 hours.

Possible side effects include sleepiness, muscle twitching, ringing in the ears, changes in vision, low blood pressure, and an irregular heart rate. Concerns exist that injecting it into a joint can cause problems with the cartilage. Concentrated bupivacaine is not recommended for epidural freezing. Epidural freezing may also increase the length of labor. It is a local anaesthetic of the amide group.

Bupivacaine was discovered in 1957. It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.Bupivacaine is available as a generic medication and is not very expensive .

 

Clinical Common usage

Bupivacaine hydrochloride is 2-Piperidinecarboxamide, 1-butyl-N-(2, 6-dimethylphenyl)-, monohydrochloride, monohydrate, a white crystalline powder that is freely soluble in 95 percent ethanol, soluble in water, and slightly soluble in chloroform or acetone .

Local or regional anesthesia or analgesia in surgical procedures (including oral surgery), diagnostic and therapeutic procedures, and obstetrical procedures .

Use of the 0.75% solution of bupivacaine hydrochloride not recommended for obstetrical epidural anesthesia.

 

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Mepivacaine hydrochloride

Anti-inflammatory Topical Pain Relief Powders Mepivacaine hydrochloride CAS 1722-62-9

 

Quick Details for Mepivacaine hydrochloride

Product Name : Mepivacaine hydrochloride
Synonyms : (1-methyl-dl-piperidine-2-carboxylicacid)-2,6-dimethylanilidehydrochloride;1-methyl-2’,6’-pipecoloxylididehydrochloride;6’-pipecoloxylidide,1-methyl-2monohydrochloride;carbocainehydrochloride;dl-1-methyl-2’,6’-pipecoloxylididehydrochloride;dl-mepivacainehydrochloride;n-(2,6-dimethylphenyl)-1-methyl-2-piperidinecarboxamidmonohydrochloride;1-methyl-2′,6′-pipecoloxylidine hydrochloride
CAS : 1722-62-9
MF : C15H22N2O.ClH
MW : 282.81
EINECS : 217-023-9
Product Categories : Sodium channel;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
Melting point : 255-257°C (dec.)
Storage temp. : Refrigerator
Chemical Properties : White Solid
Usage : anesthetic (local).
Usage : An anti-inflammatory and analgesic .

 

Mepivacaine hydrochloride Description

Mepivacaine is a local anesthetic of the amide type. Mepivacaine has a reasonably rapid onset (more rapid than that of procaine) and medium duration of action (shorter than that of procaine) and is marketed under various trade names including Carbocaine and Polocaine .

Mepivacaine is used in any infiltration and regional anesthesia .

It is supplied as the hydrochloride salt of the racemate, which consists of R(-)-mepivacaine and S(+)-mepivacaine in equal proportions. These two enantiomers have markedly different pharmacokinetic properties.

 

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Ropivacaine Hydrochloride

USP35 Pharmaceutical Grade Local Anesthetic Drugs Ropivacaine Hydrochloride 98717-15-8

 

Quick Details for Ropivacaine Hydrochloride

Product Name : Ropivacaine Hydrochloride
Synonyms : Ropivcacaine Hydrochloride;Ropivacaine HCL;Ropivacaine mesilate;
(S)-Ropivacaine Hydrochloride;S-Ropivacaine HCL;
N-(2,6-dimethylphenyl)-1-propyl-piperidine-2-carboxamide hydrochloride;
(2S)-N-(2,6-dimethylphenyl)-1-propyl-pipecolinamide hydrochloride
CAS : 98717-15-8
MF : C17H27ClN2O
MW : 310.86
Standard : USP35
Assay : 99%
Character : White powder
Usage : Anesthetic (local)
Packing : 25kg/drum
Storage : Store at room temperature away from moisture and heat.

 

Ropivacaine Hydrochloride Application

Ropivacaine is a local anaesthetic drug belonging to the amino amide group. The name ropivacaine refers to both the racemate and the marketed S-enantiomer.

Ropivacaine is an anesthetic (numbing medicine) that blocks the nerve impulses that send pain signals to your brain.

Ropivacaine is used as a local (in only one area) anesthesia for a spinal block, also called an epidural. The medication is used to provide anesthesia during a surgery or C-section, or to ease labor pains.

Ropivacaine may also be used for purposes not listed in this medication guide.

 

Ropivacaine Hydrochloride Clinical Use & Indications

Ropivacaine is indicated for local anaesthesia including infiltration, nerve block, epidural and intrathecal anaesthesia in adults and children over 12 years. It is also indicated for peripheral nerve block and caudal epidural in children 1-12 years for surgical pain. It is also sometimes used for infiltration anaesthesia for surgical pain in children .

Ropivacaine is often coadministered with fentanyl for epidural analgesia , for example in pregnant women during labour .

 

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Levobupivacaine Hydrochloride

Levobupivacaine Hydrochloride Local Anesthetic Powder CAS 27262-48-2

 

Quick Details for Levobupivacaine Hydrochloride

Product name : Levobupivacaine Hydrochloride
Synonyms: TIMTEC-BB SBB001337;(S)-(-)-BUPIVACAINE HCL;(S)-(-)-BUPIVACAINE HYDROCHLORIDE;(S)-(-)-1-N-BUTYL-2′,6′-DIMETHYL-2-PIPERIDINCARBOXANILID HYDROCHLORIDE;(S)-(-)-1-BUTYL-2-(2,6-XYLYLCARBAMOYL)-PIPERIDINE HYDROCHLORIDE;s-(-)-1-butyl-2′,6′-pipecoloxylidide hydrochloride;(s)-1-butyl-2’,6’-piperidinecarboxamidemonohydrochloride;(s)-1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamidemonohydrochloride
CAS: 27262-48-2
MF: C18H29ClN2O
MW: 324.89
Product Categories: Pharmaceutical Raw Materials;Active Pharmaceutical Ingredients
Mol File: 27262-48-2.mol
mp 254 °C (dec.)(lit.)
alpha -12.5 º (c=2, water)
Chemical Properties : White crystalline powder
Usage : Local anaesthetic drug .

 

Levobupivacaine Hydrochloride Description

Levobupivacaine Hydrochloride is the hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property.

Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.

Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AbbVie under the trade name Chirocaine.

 

Levobupivacaine Hydrochloride Clinical use

Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time.

 

Levobupivacaine Hydrochloride Indications

Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children.

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Articaine Hydrochloride

Articaine Hydrochloride Epinephrine 23964-57-0 Articaine HCL Local Anesthetic

 

Quick Details of Articaine hydrochloride

Name: Articaine hydrochloride
CAS No.: 23964-57-0
Formula: C13H20N2O3S.HCl
Molecular Weight: 320.84
Synonyms: Articaine HCL;2-Thiophenecarboxylicacid, 4-methyl-3-[2-(propylamino)propionamido]-, methyl ester,monohydrochloride (8CI);2-Thiophenecarboxylic acid,4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-, methyl ester,monohydrochloride (9CI);Carticain;Carticainechlorhydrate;Carticaine hydrochloride;Methyl4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylatehydrochloride;Septanest;Ubistesine;Ultacain;Ultracain;Ultracaine;
EINECS: 245-957-7
Boiling Point: 440.6 °C at 760 mmHg
Flash Point: 220.3 °C
Appearance: white powder
Usage : local anesthetic(Oral use) .

 

Articaine hydrochloride Description

This drug was first synthesized by Rusching in 1969,and brought to the market in Germany by Hoechst AG, a life-sciences German company, under the brand name Ultracain. This drug was originally referred to as “carticaine” until 1984.

In 1983 it was brought into the North American market, to Canada, under the name Ultracaine for dental use, manufactured in Germany and distributed byHoechst-Marion-Roussel. This brand is currently manufactured in Germany bySanofi-Aventis and distributed in North America by Hansamed Limited (since 1999). After Ultracaine’s patent protection expired, new generic versions arrived to the Canadian market: (in order of appearance) Septanest (Septodont), Astracaine, (originally by AstraZeneca and now a Dentsplyproduct), Zorcaine (Carestream Health/Kodak) and Orabloc (Pierrel).

It was approved by the FDA in April 2000, and became available in the United States of America two months later under the brand name Septocaine, ananesthetic/vasoconstrictor combination with Epinephrine 1:100,000 (trade nameSeptodont). Zorcaine became available there a few years later, also. Articadent (Dentsply) became available in the United States in October 2010. The three brands currently available in the United States are all manufactured for these companies by Novocol Pharmaceuticals Inc. (Canada). Ubistesin and Ubistesin Forte (3M ESPE) are also widely used in the United States and Europe. Orabloc (Pierrel) is aseptically manufactured and was approved by the FDA in 2010, became available in Canada in 2011, and in Europe from 2013.

 

Articaine hydrochloride Application

Articaine is a local anaesthetic that has been approved overseas for several years.Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve.This action is prolonged by combining the drug with a vasoconstrictor .

The combination of articaine and adrenaline can be used for local or regional anaesthesia for dental procedures.

 

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Lidocaine Hydrochloride

Pharma Grade Local Anesthetic Lidocaine Hydrochloride Injection CAS 73-78-9

 

Quick Detail of Lidocaine hydrochloride

Product name : Lidocaine hydrochloride
Synonyms : 2-DIETHYLAMINO-N-(2’6′-DIMETHYLPHENYL)ACETAMIDE HCL; 2-DIETHYLAMINO-N-[2, 6-DIMETHYLPHENYL]ACETAMIDE HCL
Assay : 98%
CAS No. : 73-78-9
EINECS No. : 200-803-8
Molecular Formula : C14H23ClN2O
Molecular Weight : 270.8
Melting point : 80-82° C
Boiling point : 350.8° C at 760 mmHg
Flashing point : 166° C
Storage : Refrigerator
Appearance : White crystalline powder
Packing : 25KG/Drum
Usage : Local anesthetics ; Antiarrhythmic agent .

 

Lidocaine hydrochloride Description

Lidocaine hydrochloride is a white powder without smell and with a bitter taste that is used both in human and veterinary medicine. The drug is also known as lignocaine hydrochloride, and is used as a local anesthetic and to regulate certain medical problems related to heart rhythm. Injections of it are used to provide local anesthesia during various minor surgical procedures. It is also available in various topical preparations, such as gels, sprays, creams, and ointments that are usually applied to the skin or the mucous membranes. This drug was first manufactured in Sweden in 1943 and was then named xylocaine.

When used for anesthetic purposes, lidocaine hydrochloride works by blocking certain functions of the nervous system, inhibiting the transmission of pain impulses from the treated area to the brain. It is a fast-acting form of local anesthesia that often starts to work within five minutes. The effects wear off in a relatively short time, often a couple of hours, because the drug is quickly metabolized by the liver.

 

Lidocaine hydrochloride Application

Lidocaine hydrochloride is used on the skin to stop itching and pain from certain skin conditions (e. G., scrapes, minor burns, eczema, insect bites) and to treat minor discomfort and itching caused by hemorrhoids and certain other problems of the genital/anal area (e. G., anal fissures, itching around the vagina/rectum). Some forms of this medication are also used to decrease discomfort or pain during certain medical procedures/exams (e. G., sigmoidoscopy, cystoscopy). Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes.

 

Lidocaine hydrochloride Usage

1)This medication is used on the skin to stop itching and pain from certain skin conditions (e.g., scrapes, minor burns, eczema, insect bites) and to treat minor discomfort and itching caused by hemorrhoids and certain other problems of the genital/anal area (e.g., anal fissures, itching around the vagina/rectum). Some forms of this medication are also used to decrease discomfort or pain during certain medical procedures/exams (e.g., sigmoidoscopy, cystoscopy). Lidocaine is a local anesthetic that works by causing temporary numbness/loss of feeling in the skin and mucous membranes.
2)Local anesthesic;Na+ channel blocker
3)Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.

 

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