Estradiol

Hair Regrowth Pharmaceutical Raw Powders Estradiol CAS 57-91-0

 

Quick Details for Estradiol

Product Name: Estradiol
Synonyms: 1,3,5-estratriene-3,17-alpha-diol;1,3,5-Estratriene-3,17alpha-diol;17alpha-Oestradiol;3,17alpha-Dihydroxyestra-1,3,5(10)-triene;3,17-alpha-dihydroxyoestra-1,3,5(10)-triene;3,17alpha-Dihydroxyoestra-1,3,5(10)-triene;5(10)-triene-3,17-diol,(17-alpha)-estra-3;epiestradial
CAS: 57-91-0
MF: C18H24O2
MW: 272.38
EINECS: 200-023-8
Product Categories: Steroids;Intermediates & Fine Chemicals;Pharmaceuticals
Melting point : 176-180 °C(lit.)
Storage temp. : 0-6°C
Chemical Properties : White Solid
Usage : Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.

 

17alpha-Oestradiol/ Estradiol Description

(1) Estradiol is a sex hormone that is present in both males and females, and is the most important form of estrogen in humans. In women, it plays a key role in the development and functioning of the reproductive system, as well as in the growth of certain bones. It also governs the distribution of body fat in women and is the main hormone responsible for the fact that women are shorter than men, on average. Both the ovaries and the adrenal glands produce it.

(2) The menstrual cycle in women involves predictable variations in the levels of several hormones, with estradiol being one of them. It is involved in the ovulation process and prepares the inner lining of the uterus for implantation, should the egg be fertilized. Certain tests done on baboons and other primates have indicated that his hormone also plays a continual role in maintaining a pregnancy, helping it to last for the full gestation period.

 

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Melatonine

Nutritional Supplements Raw Powders Improve Sleeping Melatonine 73-31-4

 

Quick Details for Melatonine

Product Name: Melatonine
Synonyms: Acetamide, N-[2-(5-methoxy-1H-indol-3-yl)ethyl]-;Acetamide, N-[2-(5-methoxyindol-3-yl)ethyl]-;Acetamide,N-[2-(5-methoxy-1H-indol-3-yl)ethyl];Melatonin(N-Acetyl-5-methoxytryptamine);n-(2-(5-methoxy-1h-indol-3-yl)ethyl)-acetamid;n-(2-(5-methoxyindol-3-yl)ethyl)-acetamid;N-ACETYL-5-METHOXYTRYPTAMINE;N-[2-(5-METHOXY-1H-INDOL-3-YL)ETHYL]ACETAMIDE
CAS: 73-31-4
MF: C13H16N2O2
MW: 232.28
EINECS: 200-797-7
Product Categories: Heterocyclic Series;Heterocycles series;Indoles;Tryptamines;Nutritional Supplements;Intermediates & Fine Chemicals;Pharmaceuticals;Melatonin receptor;Amines;Heterocycles;Melatonins;Alkaloid;Bioactive Small Molecules;Building Blocks;C13 to C27;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Heterocyclic Building Blocks;M;Neurobiology;Neuroscience;Nutrition Research;Pharmacologicals;Phytochemicals by Chemical Classification;Vitamin series;Herb extract;Melatonex;inhibitor;Other APIs;Cosmetics;cosmetics materials;bulk drug material;Inhibitors
Melting point : 116.5-118 °C(lit.)
Chemical Properties : Off-White Powder
Usage : Hormone postulated to mediate photoperiodicity in mammals. Inhibits cerebellar nitric oxide synthetase .
Usage : sleep induction, modifies circadian rhythm, antioxidant, free radical scavenger .
Usage : Immunostimulant;Melatonin receptor ligand .
Usage : Hormone; mediates photoperiodicity in mammals; inhibits cerebellar nitric oxide synthetase; peroxynitrite scavenger. Melatonin has complex effects on apoptotic pathways, inhibiting apoptosis in immune cells and neurons but enhancing apoptotic cell death of cancer cells. Inhibits proliferation/metastasis of breast cancer cells by inhibiting estrogen receptor action.

 

A hormone secreted by the pineal gland cells

Melatonin is a hormone secreted by the pineal gland, and its chemical structure was 5- methoxy -N- acetyl tryptamine, the physiological function of inhibiting gonad, thyroid, adrenal gland, parathyroid gland and pituitary function, inhibit precocious puberty, reduce pituitary Melanotropin secretion; and has a central nervous system function, can improve the convulsion the threshold, cause drowsiness. When pinealectomy after the animal experiment showed hyperplasia of the glands, weight increase, especially sex and sexual organs of immature rats early, pituitary secretion of LH and FSH increased, increasing secretion of thyroid and adrenal cortex hormone melatonin. More reduced pituitary MSH and whiten the skin of this role. Effects on the central nervous system, in the human EEG showed slow rhythm, increased seizure threshold, sleepiness, but does not affect their behavior and personality, of temporal lobe epilepsy and Ba Jinsen disease can reduce the motor nerve Abnormal EEG changes.

 

Melatonin Uses

1. Melatonin can be used as medicine health care products, so as to enhance people’s immune function, preventing aging and back to youth. What’s more, it is also a kind of natural “sleeping pill”.

2. Melatonin is a kind of hormone secreted by pineal body of pituitary gland in the body. The amount of melatonin has something to do with light. The weaker the light is, the more the melatonin is, whereas the less. In addition, it is helpful to one’s sleep.

3. Biochemical research.

 

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Spironolactone

Hair Loss Treatment Powders Spironolactone CAS 52-01-7 with Pure Purity

 

Quick Details for Spironolactone

Product Name: Spironolactone
Synonyms: 3-(3-keto-7-alpha-acetylthio-17-beta-hydroxy-4-androsten-17-alpha-yl)propion
CAS: 52-01-7
MF: C24H32O4S
MW: 416.57
EINECS: 200-133-6
Product Categories: Active Pharmaceutical Ingredients;Biochemistry;Steroids;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;API’s;ALDACTONE
Melting point : 207-208 °C(lit.)
Storage temp. : Store at RT
Chemical Properties : White to Off White Solid
Usage : It is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia .
Usage : diuretic, aldosterone antagonist .

 

Spironolactone Diuretics

Spironolactone is a kind of weak potassium-sparing diuretics, and is fine white or white-like crystalline powder with slightly bitter taste. It is odorless or with slight mercaptan odor. It is highly soluble in chloroform but insoluble in water and soluble in ethanol, and easily soluble in benzene or ethyl acetate. It has a similar chemical structure as aldosterone and can compete with aldosterone for the aldosterone receptors in the cytoplasm of the distal convoluted tubule and collecting tube duct cells, affecting the binding of the aldosterone to its receptor, thus preventing the synthesis of aldosterone-induced protein and further inhibiting the exchange between K+ and Na+ with reduced potassium excretion and plays potassium-sparing diuretic effect. The strength of the diuretic effect of spironolactone is related to the in vivo secretion of aldosterone with increased secretion also causing stronger effect while lower secretion causing weaker effects. It has no diuretic effect on patients without aldosterone secretion. Because the drug only acts on the distal convoluted tubule and collecting duct while having no effect on the other segments of tubular, it only has a weak diuretic effect with slow onset but long duration time. It is mainly used for treating refractory edema accompanied with higher amount of aldosterone such as cirrhosis, congestive heart failure, and nephrotic syndrome with excellent efficacy in treating the patients with hyperaldosteronism caused by the lack of sodium in the congestive heart failure. Single drug administration usually only give a poor diuretic and therefore, it is often used in combination with hydrochlorothiazide or dihydrochlorothiazide for enhancing the effect. In addition, it can also be applied to the treatment of primary hyperaldosteronism and hypertension. Patients of hyperkalemia or renal failure should be disabled.

This product has a rapid and irregular absorption rate after oral administration with the absorption rate being relate to the spironolactone particle size. According to general process, the bioavailability is only about 5% while the absorption rate can reach 90% when made into fine particles with the time for the plasma concentration reaching the peak with approximately 3 hours. It has rapid metabolism rate in vivo with its major metabolites being canrenone which can exert the pharmacological activity and other metabolites also being gradually converted into canrenone. The serum metabolites level will reach peak at 2 to 4 hours after single dose of oral administration. The concentration of metabolites will decrease rapidly within 12 hours with slow decline in 12 to 96 hours. After oral administration of multiple doses, the half life of the canrenone metabolite was 13 to 24 hours. The half-life of spironolactone is only about 10 minutes. The plasma protein binding rate of canrenone is about 98%. Its metabolites can be secreted through the bile and urine. The canrenone metabolism includes enterohepatic circulation. It can penetrate through the placental barrier and enter into breast milk. It also has effects of inhibiting estrogen and androgen synthesis.

 

Spironolactone Indications

Spironolactone is a kind of competitive aldosterone inhibitors with the drug itself being not active. Its diuretic effect is through its competitive antagonism against endogenous aldosterone, belonging to potassium-sparing diuretics.

1. edema disease, being used in combination other diuretics for the treatment of congestive heart failure, liver cirrhosis, renal edema, edema disease; the purpose in to correct the increased secondary aldosterone secretion associated with those above diseases and fight against the potassium excretion of other diuretics; it can also used in the treatment of idiopathic edema.

2. Hypertension, as the auxiliary treatment drug of high blood pressure.

3. For primary hyperaldosteronism, spironolactone can be used to diagnose and treat the disease.

4. For the prevention of hypokalemia; being used in combination with thiazide diuretics to enhance the diuretic effect and prevent hypokalemia.

 

Spironolactone Uses

It can be used as a kind of inefficient diuretic drugs .

It is a synthetic 17-lactone steroid which is a kind of renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension and hypokalemia .

The active metabolite of lactone (spironolactone); It can be used for the Inhibition of aldosterone biosynthesis. It can also be used as the blocker of the Quabain effect .

 

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Ketoconazole

Medicine For Hair Loss Treatment Ketoconazole CAS 65277-42-1

 

Quick Details for Ketoconazole

Product Name: Ketoconazole
Synonyms: fungarest;fungoral;ketoconazol;ketoderm;ketoisdin;kw-1414;nizoral
CAS: 65277-42-1
MF: C26H28Cl2N4O4
MW: 531.43
EINECS: 265-667-4
Product Categories: Active Pharmaceutical Ingredients;Organics;Antifungals for Research and Experimental Use;Antitumors for
Research and Experimental Use;Biochemistry;Antibiotic Explorer;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;
API;API’s;Antifungal;Heterocycles;Isotopically Labeled Pharmaceutical Reference Standard;KETOZOLE
Melting point : 146°C
Refractive index : -10.5 ° (C=0.4, CHCl3)
Storage temp. : 2-8°C
Chemical Properties : White Powder
Usage : Antifungal, PXR/SRC1 & CAR/SRC1 inhibitor
Usage : For the treatment of the following systemic fungal infections: candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis.
Usage : Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor .
Uses : It is antifungal drug for being used to treat athlete’s foot and excessive dandruff.

 

Antifungal drug

Ketoconazole is a broad-spectrum antifungal imidazole with commercially available product being under the trade name of Jindakening, Meikangling and keNing. It interferes with the activity of fungal cytochrome P-450 with a high selectivity, thus inhibiting the biosynthesis of ergosterol in fungal cell membrane. It is effective in treating both shallow, deep fungal infections and can inhibit both fungal growth and the transition from spores to mycelium to prevent the further infection. It has antifungal effect on Candida genus, Fonsecaea, Coccidioides, Histoplasma, Sporothrix spp and Trichophyton. Clinically, it is suitable for the treatment of ringworm, athlete’s foot, and skin ringworm, tinea, jock itch, and thrush, tinea versicolor as well as cutaneous candidiasis.

Ketoconazole lotion, as a skin external use, is mainly used for clinical treatment and prevention of various kinds of infections caused by Malassezia such as tinea versicolor, seborrheic dermatitis and scalp pityriasis (dandruff), and can quickly alleviate the desquamation and itching caused by seborrheic dermatitis and scalp pityriasis.

 

Pharmacological effects

1. Pharmacology: ketoconazole belongs to azole-class antifungal drugs and has antifungal activity against various kinds of genus of deep fungal infections such as Candida, Fonsecaea, Coccidioides, Histoplasma, Sporothrix spp as well as Trichophyton. However, this product has a relative weak activity against Aspergillus, Sporothrix schenckii as well as some species of Dermateaceae and Mucor. This product, through actively interfering with the activity of cytochrome P-450, is capable of inhibiting the biosynthesis of the major steroids – ergosterol of the fungal cell membrane. Therefore, it destroys the fungal cell membrane and changes its permeability, resulting in the leakage of important intracellular material. Ketoconazole can also inhibit the biosynthesis of fungal triglyceride and phospholipid biosynthesis, inhibit the activity of oxidase and peroxidase, causing accumulation of intracellular hydrogen peroxide which further leads to cell submicroscopic structural degeneration and necrosis. For candida albicans, it can also suppress the transition process from spores to aggressive mycelium.

2. Toxicology: Long-term animal toxicity experiments have showed that ketoconazole can significantly increase the level of alkaline phosphatase and cause liver cell degeneration.

 

Indications

Ketoconazole is suitable for treating the following systemic fungal infections:

1. Candidiasis, chronic mucocutaneous candidiasis, oral candidiasis infection, Candida urinary tract infections as well as chronic, recurrent vaginal candidiasis which can be cured by topical therapy.
2. Dermatitis blastomycosis.
3. Coccidioidomycosis.
4. Histoplasmosis.
5. Chromomycosis.
6. Paracoccidioidomycosis.

It can be used for treating fungal skin diseases, hair ringworm and tinea versicolor caused by fungi and yeasts. When local therapy or oral administration of griseofulvin is invalid, or griseofulvin is unacceptable in the treatment of severe refractory fungal skin infection, we can choose the treatment of this drug.

 

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Minoxidil

Hair Loss Treatment Medicine Minoxidil 38304-91-5 for Regrowth

 

Quick Details for Minoxidil

Product Name: Minoxidil
Synonyms: 2,3-dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine;2,4-diamino-6-piperidinilpirimidina-3-ossido;2,4-diamino-6-piperidino-pyrimidin3-oxide;2,4-diamino-6-piperidinopyrimidine3-n-oxide;4-pyrimidinediamine,6-(1-piperidinyl)-3-oxide;6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine;6-piperidino-2,4-diaminopyrimidine3-oxide;alopexil
CAS: 38304-91-5
MF: C9H15N5O
MW: 209.25
EINECS: 253-874-2
Product Categories: API;Intermediates & Fine Chemicals;Pharmaceuticals;API’s;Potassium channel;Heteroctcles;Bases & Related Reagents;Nitric Oxide Reagents;Nucleotides;ROGAINE;Other APIs
Melting point : 272-274 °C (dec.)(lit.)
Storage temp. : Store at RT .
Chemical Properties : White Crystalline Solid
Usage : antihypertensive, antialopecia agent.
Usage : A selective ATP dependent K+ (Kir6) channel activator.
Usage : Used as an antihypertensive and antialopecia agent. Minoxidil activates ATP-activated K+ channels.

 

An antihypertensive vasodilator medication

Minoxidil is an antihypertensive vasodilator medication also claiming to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes, if experienced, disappear within months after discontinuation of treatment.

Minoxidil was first sold as a drug for high blood pressure and was noted to have the interesting side-effect of increased body hair-growth, or in some cases, significant hair loss. Treatments for baldness and hair loss usually include a 5% concentration solution that is designed for men, whereas the 2% concentration solutions are designed for women.

 

Minoxidil Description

Minoxidil is currently the world’s only significant effect hair loss topical chemical drugs . This medicine is used to lower blood pressure orally . If an external high doses , the drug will be absorbed into the body through the skin , may cause headache, hypotension. If you accidentally dropped his face , may cause the drop of the Department overgrown hairs . But it is precisely because ” Minoxidil ” is currently the world’s only significant effect hair loss topical chemical drugs .

 

Minoxidil Application

Minoxidil is an antihypertensive drug and a hair growth stimulant Vasodilator; treatment of hypertension; male pattern baldness.

Minoxidil is a vasodilator medication known for its ability to slow or stop hair loss and promote hair regrowth. It is available over the counter for treatment of androgenic alopecia, among other baldness treatments, but measurable changes disappear within months after discontinuation of treatment. Its effectiveness has largely been demonstrated in younger men (18 to 41 years of age), the younger the better, and in those with balding in the central (vertex) portion of the scalp .

Minoxidil is a potassium channel agonist. It contains the chemical structure of nitric oxide), a blood vessel dilator, and may be a nitric oxide agonist. This appears to explain its vasodilatory effects, but may also be linked to minoxidil’s ability to stimulate hair growth and treat hair loss. Since minoxidil is a nitric oxide-related compound, it was suspected to act via activation of guanylate cyclase, an enzyme involved in vasodilation.

 

Minoxidil Usage

Lowering high blood pressure in patients who do not respond to other therapy.

Minoxidil is a vasodilator. It reduces blood pressure by relaxing and dilating (widening) blood vessels. Blood flows more freely and at a lower pressure through dilated blood vessels .

 

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Finasteride

Hair Loss For Treatment Medicine Finasteride 98319-26-7

 

Quick Details for Finasteride

Product Name: Finasteride
Synonyms: PROSCAR;PROSTIDE;N-(2-METHYL-2-PROPYL)-3-OXO-4-AZA-5ALPHA-ANDROST-1-ENE-17BETA-CARBOXAMIDE;MK-906;(5alpha,17beta)-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide;17beta-(n-tert-butylcarbamoyl)-4-aza-5alpha-androst-1-en-3-one;4-azaandrost-1-ene-17-carboxamide,n-(1,1-dimethylethyl)-3-oxo-,(5-alpha,17-be;4-azaandrost-1-ene-17-carboxamide,n-(1,1-dimethylethyl)-3-oxo-,(5alpha,17beta
CAS: 98319-26-7
MF: C23H36N2O2
MW: 372.54
Product Categories: Active Pharmaceutical Ingredients;API;Biochemistry;Steroids;Steroids (Others);Intermediates & Fine Chemicals;Pharmaceuticals;Vitamin Ingredients;Intracellular receptor;Steroid and Hormone;PROSCAR;Hormone Drugs
Melting point : 253 °C
Storage temp. : Store at RT
Chemical Properties : Off-White Crystalline Powder
Usage : Inhibitor of 5a-reductase, the enzyme which converts testosterone to the more potent androgen, 5a-dihydrotestosterone. Antialopecia agent
Usage : Inhibitor of 5α-reductase, the enzyme which converts testosterone to the more potent androgen, 5α-dihydrotestosterone. Antialopecia agent.
Usage : anti-androgen, alpha-reductase inhibitor.
Usage : Treatment of benign prostatic hyperplasia and androgenetic alopecia .

 

Treatment of benign prostatic hyperplasia

Finasteride is China a benign prostatic hyperplasia and prostatitis based drug treatment, it is 4 – nitrogen steroid hormone compounds of the synthesis, belonging to resistance hormone drugs, can be selective inhibition of 5α- reductase, enable the conversion of testosterone into resistance 5α dihydrotestosterone (DHT), front row in glandular cells of the male hormone levels drop, reduce the serum prostate specific antigen, reduce the prostate volume increased, urine flow increased, thereby reducing symptoms to achieve the purpose for the treatment of benign prostatic hyperplasia.

Prostatic hyperplasia is called hypertrophy of the prostate, leading to the bladder neck and urethra oppressed, causing urinary tract obstruction and other symptoms and complications, so that patients feel pain, multiple men over the age of 50.

 

Drugs for the treatment of male pattern alopecia

Finasteride is a 5α- reductase inhibitor, is hormone resistant drugs, it can prevent converts testosterone to dihydrotestosterone (DHT), so as to reduce of DHT synthesis, reduce the content of scalp hair and serum dihydrotestosterone. Germinal function recovery has been suppressed follicular papilla, promoting hair growth and preventing hair loss, finasteride is currently approved by the U.S. Food and Drug Administration (FDA) only for male pattern hair loss of oral drug treatment, the recommended dose is 1mg.

 

Finasteride Uses

1. 5αreductase inhibitors can inhibit the conversion of testosterone to dihydrotestosterone. Used for the treatment of benign prostatic hyperplasia.

2. Use for the treatment of male diseases such as prostate hypertrophy and alopecia.

 

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Dutasteride

Medicines For Hair Loss Treatment Dutasteride 164656-23-9

 

Quick Details for Dutasteride

Product Name: Dutasteride
Synonyms: (5alpha,17beta)-n-{2,5-bis(trifluoromethyl)phenyl}-3-oxo-4-azaandrost-l-ene-17-carboxamide;DUTASTERIDE;GG-745, GI-198745,;5α,17β)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4- Aza -androst-1-ene-17-carboxamide;Duagen;(5a,17)-N-[2,5-Bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide;Avodart;GI 198745
CAS: 164656-23-9
MF: C27H30F6N2O2
MW: 528.53
Product Categories: Miscellaneous Biochemicals;All Inhibitors;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone;Hormone Drugs;API
Melting point : 242-250°C
Storage temp. : Keep in room temperature .
Chemical Properties : White Crystalline Solid
Usage : Used in the treatment of benign prostatic hyperplasia. Dual inhibitor of 5a-reductase isoenzymes type 1 and 2; structurally related to Finasteride.
Usage : Used in the treatment of benign prostatic hyperplasia. Dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride.
Usage : antihypertensive, ACE inhiibitor .
Usage : Dutasteride is a dual inhibitor of 5α-reductase isoenzymes type 1 and 2; structurally related to Finasteride (F342000). Dutasteride is used in the treatment of benign prostatic hyperplasia.

 

Dutasteride Applications

Dutasteride reduce the overall risk of being diagnosed with prostate cancer; however, there is insufficient data to determine if they have an effect on the risk of death and may increase the chance of more serious cases.

Dutasteride is used alone or in combination with tamsulosin (Flomax) to treat men who have symptoms of an enlarged prostate gland, which is also known as benign prostatic hyperplasia (BPH). Benign enlargement of the prostate is a problem that can occur in men as they get older. The prostate gland is located below the bladder.

As the prostate gland enlarges, Dutasteride ,certain muscles in the gland may become tight and get in the way of the tube that drains urine from the bladder.As the prostate gland enlarges, certain muscles in the gland may become tight and get in the way of the tube that drains urine from the bladder. This can cause problems with urinating, such as a need to urinate often, a weak stream when urinating, or a feeling of not being able to empty the bladder completely.

Dutasteride is used in the treatment hyperplasia and androgenic alopecia. Because these drugs reduce levels of (DHT). they are used to prevent and treat hairloss. It is most commonly used to treat enlarged prostate glands .

 

Dutasteride Function

Dutasteride is marketed pharmaceutically as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost. For unknown reasons, early clinical trials for dutasteride were abruptly ceased in 2002, then continued later.

Dutasteride is a 5-alpha-reductase inhibitor, meaning it blocks the action of the 5a-reducatse enzymes, that are responsible for 5a-reducing (converting) testosterone into dihydrotestosterone (DHT) by the addition of a double hydrogen bond.

Dutasteride inhibits both isoforms of 5a-reductase, therefore preventing the conversion of into . This makes Dutasteride a reasonable treatment for Male Pattern Baldness. Of course, when you convert less Testosterone into , you increase testosterone levels by default (less conversion).

 

Dutasteride Dosage For Treating Hair loss

Dutasteride, at 2.5mgs/day is roughly 1.5x more effective than Finasteride at 5mgs/day, at treating hair loss (both halting it as well as regrowing it).

Dutasteride,In addition, Dutasteride can be used successfully at that same dose to treat prostate enlargement, and a lesser known effect of Dutasteride (again, at that same dose) use is to treat Acne caused by an overabundance of androgens in the body.

 

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