Clobetasol Propionate

Topical Corticosteroid Anti-inflammatory Raw Powders Clobetasol Propionate CAS 25122-46-7

 

Quick Details for Clobetasol Propionate

Product Name: Clobetasol propionate
Synonyms: 17-propionate;cgp9555;clobesol;pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-me;CLOBESTASOL PROPIONATE;CLOBETASOL-17-PROPIONATE;CLOBETASOLE PROPIONATE;CLOBETASOL PROPIONATE
CAS: 25122-46-7
MF: C25H32ClFO5
MW: 466.97
EINECS: 246-634-3
Product Categories: Organics;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pharmaceutical intermediate;TORADOL;Hormone Drugs;Halogenated Heterocycles ,Pyrazines ,Pyrans
Melting point : 195.5-197℃
Storage temp.: -20°C Freezer
Chemical Properties : White Crystalline Powder
Usage : For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Usage Topical corticosteroid. Glucocorticoid; anti-inflammatory.

 

Clobetasol Propionate Descriptions

Clobetasol Propionate is a highly potent topical steroid.It has both local anti inflammatory and immunosuppressive activity.Clobetasol, as the Propionate salt, is only used topically on the skin and its effects are limited to the local anti-inflammatory activity.

Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several autoimmune diseases including alopecia areata, vitiligo, lichen sclerosus, and lichen planus.

Clobetasol propionate is marketed and sold worldwide under numerous names including Clobex, Clob-x (Colombia),Clovate, Cormax (Watson, US), Pentasol (Colombia), Cosvate (India), Temovate (US), Dermovate (GlaxoSmithKline, Pakistan, Portugal, Israel), Olux, Tenovate, Dermatovate, Butavate, Movate, Novate, and Powercort.

 

Pharmacology toxicology

This product is rapid, the current clinical application of effective topical cortico steroids medicine effect of a strong. Has the strong capillary contraction, the anti-inflammatory effects of hydrocortisone for 112.5 times, 2.3 times of betamethasone sodium phosphate, 18.7 times fluocinolone. Systemic adverse reactions for 3 times fluocinolone, anhydrous sodium retention effect, have certain promote sodium, potassium excretion .

 

Clobetasol Propionate Use

1. Clobetasol propionate is a synthetic high topical glucocorticoid drugs. Has a strong anti-inflammatory, anti itching and capillary vascular contraction, the anti-inflammatory effects of hydrocortisone is about 112.5 times, 2.3 times of betamethasone sodium phosphate, 18.7 times fluocinolone. At the same time with inhibition of cell mitosis, can effectively penetrate into the skin stratum corneum.

2. External apply to chronic eczema, neurodermatitis, psoriasis and palmoplantar pustulosis, lichen planus, discoid lupus erythematosus, glucocorticoid, topical treatment of pruritic effective and non infectious inflammatory skin disease.

3. Has the inhibitory effects of anti-inflammatory, anti allergic, anti proliferation, immune.Can compound products: ketoconazole. vitamin A acid cream and liniment.

 

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Prednisolone Acetate

Synthetic Corticosteroid Pharmaceutical Raw Materials Prednisolone Acetate 52-21-1

 

Quick Details for Prednisolone Acetate

Product Name: Prednisolone Acetate
Synonyms: Prednisolone-21-acetate
CAS: 52-21-1
MF: C23H30O6
MW: 402.48
EINECS: 200-134-1
Product Categories: Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;API;METICOTOLONE;Applicable to rheumatoid arthritis, rheumatic fever, lupus erythematosus (sle), scleroderma, dermatomyositis, acute lymphocytic leukemia, etc
Melting point : 240-244 °C
Chemical Properties : White crystalline powder
Usage : Synthetic corticosteroid; metabolically interconvertible with prednisone.
Usage : glucocorticoid .

 

Prednisolone Acetate is used for

Product features Prednisolone is a synthetic glucocorticoid, a derivative of cortisol, which is used to treat a variety of inflammatory and auto-immune conditions. It is the active metabolite of the drug prednisone[1] and is used especially in patients with hepatic failure, as these individuals are unable to metabolise prednisone into prednisolone. Prednisolone is a corticosteroid drug with predominant glucocorticoid and low mineralocorticoid activity, making it useful for the treatment of a wide range of inflammatory and auto-immune conditions such as asthma, uveitis, pyoderma gangrenosum, rheumatoid arthritis, ulcerative colitis, pericarditis, temporal arteritis and Crohn’s disease, Bell’s palsy, multiple sclerosis, cluster headaches, vasculitis, acute lymphoblastic leukemia and autoimmune hepatitis, systemic lupus erythematosus, Kawasaki disease and dermatomyositis. It is also used for treatment of sarcoidosis, though the mechanism is unknown. Prednisolone acetate ophthalmic suspension (eye drops) is an adrenocortical steroid product, prepared as a sterile ophthalmic suspension and used to reduce swelling, redness, itching, and allergic reactions affecting the eye. Prednisolone can also be used as an immunosuppressive drug for organ transplants and in cases of adrenal insufficiency (Addison’s disease).

Corticosteroids inhibit the inflammatory response to a variety of inciting agents and, it is presumed, delay or slow healing. They inhibit the edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation with inflammation. Possible side-effects include fluid retention of the face (moon face, Cushing’s syndrome), acne, constipation, and mood swings. A lengthy course of prednisolone can cause bloody or black tarry stools from bleeding into the stomach (this requires urgent medical attention); filling or rounding out of the face; muscle cramps or pain; muscle weakness; nausea; pain in back, hips, ribs, arms, shoulders, or legs; reddish-purple stretch marks on arms, face, legs, trunk, or groin; thin and shiny skin; unusual bruising; urinating at night; rapid weight gain; and wounds that will not heal. Prolonged use of prednisolone can lead to the development of osteoporosis which makes bones more fragile and susceptible to fractures. One way to help alleviate this side effect is through the use of calcium and vitamin D supplements.

This medication is used to treat certain eye conditions due to inflammation or injury. Prednisolone acetate works by relieving symptoms such as swelling, redness, and itching. It belongs to a class of drugs known as corticosteroids.

 

How to use prednisolone acetate ophthalmic

Unless otherwise directed by your doctor, do not wear contact lenses while you are using this medicine. Sterilize contact lenses according to the manufacturer’s directions, and check with your doctor before you begin using them again .

If your doctor does approve the wearing of contact lenses during treatment with this medication, remove the lenses before using the eye drops. The preservative in this product may be absorbed by contact lenses. Wait at least 15 minutes after each dose of the eye drop before wearing the lenses again .

 

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Hydrocortisone acetate

Adrenal cortical hormone drugs Hydrocortisone acetate CAS 50-03-3

 

Quick Details for Hydrocortisone acetate

Product Name: Hydrocortisone acetate
Synonyms: (11beta)-21-(Acetoxy)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione;11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl acetate;11-beta,17-alpha-dihydroxy-21-acetoxypregesterone;11beta17alpha-Dihydroxy-21-acetoxypregesterone;17-alpha-hydrocorticosterone21-acetate;17alpha-Hydrocorticosterone-21-acetate;17-dihydroxy-20-dion(11-beta)-pregn-4-ene-21-(acetoxy)-11;17-dihydroxy-20-dion(11beta)-pregn-4-ene-21-(acetyloxy)-11
CAS: 50-03-3
MF: C23H32O6
MW: 404.5
EINECS: 200-004-4
Product Categories: Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Veterinaries;Steroid and Hormone;Hormone Drugs;Adrenal cortical hormone drugs;API
Melting point : 223 °C (dec.)(lit.)
Fp : 223°C
Storage temp.: 0-6°C
Chemical properities : white powder
Usage : Glucocorticoid . Corticosteroid drugs, have anti-inflammatory, anti-allergic, anti-toxins, anti-shock effect.

 

Adrenocorticotropic hormone drugs

1. Hydrocortisone acetate is an adrenal hormone drugs, white crystalline powder, odorless, bitter taste. The melting point is 216 ~ 222 ℃, right optical. Slightly soluble in ethanol, ether, chloroform, acetone, insoluble in water. It was synthesized by In 17α- hydroxy progesterone.

2. Hydrocortisone acetate has important physiological activities such as anti-inflammatory, anti-viral, anti-allergic, anti-shock, reducing inflammatory exudation effect, commonly used in clinical adrenal insufficiency and autoimmune diseases. Preparations are injection, tablets, ointments and eye drops. Adding a small amount of hydrocortisone acetate in some cosmetics cortisol can increase the efficacy of anti-allergy and improve the degree of whitening of the skin, but long-term using of such substances can cause the skin produce hormone-dependent disease. Our cosmetics cosmetics specifications prescribedthathormone substances can not be added.

3. This medication is used to treat hemorrhoids and itching/swelling in the rectum and anus. It is also used with other medications to treat certain intestinal problems (such as ulcerative colitis of the rectum and other rectal/anal inflammatory conditions).Hydrocortisone suppositories help to relieve rectal pain, itching, bloody diarrhea, and bleeding by reducing swelling (inflammation) directly in the rectum and anus. Hydrocortisone belongs to a class of drugs called corticosteroids.

 

Medical Uses of Glucocorticoid Steroids Hydrocortisone Acetate

1. Hydrocortisone acetate injection is used to treat the following

Infection caused by the Trichinae Parasite; Sarcoidosis; Diagnostic Test For Cushing’s Syndrome; Disease with Enlarged Lymph Tissue, Spleen and Liver, Chronic Malignant T-Cell Lymphoma of the Skin, Non-Hodgkin’s Lymphoma, Type of Leukemia – Acute Lymphocytic Leukemia, Increased Calcium in the Blood from Cancer, Thyroid Gland Inflammation, Condition caused by Excess Secretion of Male Hormones, Addison’s Disease, Severely Decreased Function of the Cortex of Adrenal Gland, Decreased Function of the Adrenal Gland, Inflammation of the Joints due to Gout, Disease in which Body has Immune Response Against Itself, Destruction of Red Blood Cells by Body’s Own Antibodies, Constitutional Aplastic Anemia.

2. Hydrocortisone acetate injection may also be used to treat

Severe Newborn Breathing Problem with Blue Discoloration, Shock caused by a Severe Bacterial Infection .

 

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Triamcinolone Acetonide

Anti-inflammatory Hormone Raw Powder Triamcinolone Acetonide CAS 76-25-5

 

Quick Details for Triamcinolone Acetonide

Name:Triamcinolone acetonide
Synonyms: ARISTODERM;9ALPHA-FLUORO-11BETA,21-DIHYDROXY-16ALPHA,17-ISOPROPYLIDENEDIOXY-1,4-PREGNADIENE-3,20-DIONE;9ALPHA-FLUORO-16ALPHA-HYDROXYPREDNISOLONE 16ALPHA,17ALPHA-ACETONIDE;9ALPHA-FLUORO-11BETA,16ALPHA,17ALPHA,21-TETRAHYDROXY-1,4-PREGNADIENE-3,20-DIONE 16,17-ACETONIDE;9a-fluoro-11b,16a,17a,21-tetrahydroxy-1,4-pregnadiene-3,20-dione 16,17-acetonide;9a-fluoro-16a-hydroxyprednisolone 16a,17a-acetonide;ALPHA-FLUORO-11BETA,16ALPHA,17,21-TETRA-HYDROXYPREGNA-1,4-DIENE-3,20-DIONE
CAS: 76-25-5
MF: C24H31FO6
MW: 434.5
EINECS: 200-948-7
Product Categories: Steroids;Pharmaceuticals;Steroid and Hormone
Chemical Properties : White Solid
Usage : A glucocorticoid, antiasthmatic (inhalant); antiallergic (nasal).

 

Triamcinolone Acetonide Description

Triamcinolone acetonide as an intra-articular injectable has been used to treat a variety of musculoskeletal conditions. When applied as a topical ointment, it is used for blistering from poison ivy, oak, and sumac, applied to the skin, avoiding eyes, mouth, and genital area. It provides immediate relief and is used before using oral prednisone. Oral/dental paste preparations are used for treating aphthous ulcers.

As an intravitreal injection, triamcinolone acetonide has been used to treat various eye diseases and has been found useful in reducing macular edema. Drug trials have found it to be as efficient as anti-VEGF drugs in eyes with artificial lenses over a two-year period.

Uncommonly, intramuscular injection of triamcinolone acetonide may be indicated for the control of severe or incapacitating allergic states for which conventional treatments have failed, such as asthma, atopic dermatitis, contact dermatitis, perennial or seasonal allergic rhinitis, serum sickness, and transfusion and drug hypersensitivity reactions.

 

Triamcinolone Acetonide Usage and dosage

Intramuscular injection, once a week 20-100;

Subcutaneous or intra articular injection, general 2.5-5mg;a day not more than 30mg, a week does not exceed.

It Can also be topical ointment. Eye drops, 1 to 4 times a day. Aerosol a 3-4 times. Intraarticular injection may leads to joint damage.

Long used in eye drops can cause increased intraocular pressure.

 

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Betamethasone

Anti-inflammatory Glucocorticoid Drugs Betamethasone CAS 378-44-9

 

Quick Details for Betamethasone

Product Name: Betamethasone
Synonyms: (11beta,16beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione;16-beta-methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20;16-beta-Methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20-dione;17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-9-alpha-fluoro-11-bet;6beta)-;9-alpha-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione;9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-beta-methylpregna-1,4-diene;9-alpha-fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20
CAS: 378-44-9
MF: C22H29FO5
MW: 392.46
EINECS: 206-825-4
Product Categories: Biochemistry;Hydroxyketosteroids;Steroids;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;Pharmaceutical intermediate;CELESTONE
Melting point : 235-237°C
Storage temp.: 0-6°C
Chemical Properties : White to Off-White Solid
Usage : glucocorticoid, antiinflammatory .
Usage : Betamethasone is a glucocorticoid used as an anti-inflammatory agent.
Usage : anti-inflammatory, immunosuppressive .

 

Anti-inflammatory glucocorticoid drugs

Betamethasone, belongs to adrenal corticosteroids, it is a isomer of dexamethasone , and the role of betamethasone is similiar to prednisolone and dexamethasone , it has anti-inflammatory, anti-rheumatic, anti-allergic and suppression of the immune and other pharmacological effects, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone etc. , it can reduce and prevent tissue response to inflammation and eliminate heat, redness and swelling caused by local non-infectious inflammation, thereby reducing the performance of inflammation, anti-inflammatory effect of this product 0.3mg is equal to dexamethasone 0.75mg, prednisone 5mg or 25mg cortisone .

Betamethasone sodium retention effect is a hundred times more than hydrocortisone, in primary adrenal hypofunction, it can be used together with glucocorticoid for replacement therapy ,and it is used for preventing or inhibiting cell-mediated immune response, delaying allergic reactions and reducing the primary immune response expansion ,it is used for low renin and low aldosterone syndrome and autonomic neuropathy induced orthostatic hypotension.

Currently betamethasone is also used for the treatment of active rheumatoid arthritis, rheumatoid arthritis, lupus, severe bronchial asthma, severe dermatitis, acute leukemia, atopic dermatitis, eczema, neurodermatitis, seborrheic dermatitis, and pruritus and comprehensive treatment of certain infections.

The product is contraindicated in severe psychiatric history, active duodenal ulcer, recent gastrointestinal anastomosis, heavier osteoporosis, overt diabetes, severe hypertension, virus , bacterial, fungal infections which are failed to control by the use of antimicrobial agents , thrombophlebitis, skin infections, such as impetigo, tinea, jock itch and so on.

 

Uses

Hormone drugs.It is mainly used for anti-inflammatory and anti-allergic. It is suitable for rheumatoid arthritis and various skin diseases. Betamethasone role is similiar to dexamethasone, its anti-inflammatory effect is stronger than dexamethasone, triamcinolone, hydrocortisone and it has few side effects.

 

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Hydrocortisone

Hydrocortisone Lotion CAS 50-23-7 High Blood Calcium Raw Material Medicine

 

Quick Details for Hydrocortisone

Product Name: Hydrocortisone
Synonyms: 11,17a,21-Trihydroxy-4-pragnene-3,20-dione;11-beta,17,21-trihydroxypregn-4-ene-3,20-dione;11beta,17,21-Trihydroxypregn-4-ene-3,20-dione;11-beta,17-alpha,21-trihydroxy-4-pregnene-3,20-dione;11beta,17alpha,21-Trihydroxy-4-pregnene-3,20-dione;11-beta,17-alpha-trihydroxypregnane-4-ene-3,20-dione;11-beta-hydrocortisone;11beta-Hydrocortisone
CAS: 50-23-7
MF: C21H30O5
MW: 362.46
EINECS: 200-020-1
Product Categories: TPI;Steroids;Veterinaries;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;HYDROCORTONE;Isolabel;Hormone Drugs;adrenocortical hormones ‘ drug;API;Inhibitors
Melting point : 211-214 °C(lit.)
Chemical Properties : White crystalline powder
Usage : Principle glucocorticoid hormone produced by adrenal cortex. An anti-inflammatory hormone.
Usage : glucocorticoid, antiinflammatory
Usage : Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism .

 

Description of Hydrocortisone

Hydrocortisone (INN, USAN, BAN) is a name for cortisol when it is used as a medication. Hydrocortisone is used to treat people who lack adequate naturally generated cortisol. It is on the World Health Organization’s List of Essential Medicines, the most important medications needed in a basic health system.

Cortisol is a steroid hormone, in the glucocorticoid class of hormones, and is produced in humans by the zona fasciculata of the adrenal cortex within the adrenal gland. It is released in response to stress and low blood-glucose concentration.

 

Hydrocortisone Usage

Hydrocortisone is a steroid medication that treats inflammation in the body.
The drug comes in an oral form to take by mouth, and a topical form to apply to the skin. It’s available over-the-counter (OTC) and with a prescription for higher-strength formulations.

Hydrocortisone provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, ulcerative colitis, and flare-ups of multiple sclerosis. Hydrocortisone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions.

 

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Dexamethasone Sodium Phosphate

Glucocorticoid Steroids Intermediates Dexamethasone Sodium Phosphate CAS 2392-39-4

 

Quick Details for Dexamethasone sodium phosphate

Product Name: Dexamethasone sodium phosphate
Synonyms: DEXAMETHASON SODIUM PHOSPHATE;DEXAMETHASONE SODIUM PHOSPHATE;DEXAMETHASONE PHOSPHATE SODIUM;DEXAMETHASONE PHOSPHATE DISODIUM SALT;1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-PHOSPHATE, DISODIUM SALT;9-FLUORO-11 BETA,17 ALPHA,21-TRIHYDROXY-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-(DIHYDROGENPHOSPHATE)DIS;Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, sodium salt (1:2), (11β,16α)-
CAS: 55203-24-2
MF: C22H28FNa2O8P
MW: 516.4
EINECS: 219-243-0
Product Categories: Inhibitors
Storage temp. : 2-8°C
Appearance : White powders
Usage : An inducer of apoptosis and inhibitor of the sodium phosphate symporter .

 

Dexamethasone sodium phosphate Description

Dexamethasone sodium phosphate, a corticosteroid, is similar to a natural hormone produced by your adrenal glands. It often is used to replace this chemical when your body does not make enough of it. It relieves inflammation (swelling, heat, redness, and pain) and is used to treat certain forms of arthritis; skin, blood, kidney, eye, thyroid, and intestinal disorders (e.g., colitis); severe allergies; and asthma. Dexamethasone sodium phosphate is also used to treat certain types of cancer.

Dexamethasone sodium phosphate comes as a tablet and a solution to take by mouth. Your doctor will prescribe a dosing schedule that is best for you. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Dexamethasone sodium phosphate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

 

Dexamethasone sodium phosphate Applications

Do not stop taking Dexamethasone sodium phosphate without talking to your doctor. Stopping the drug abruptly can cause loss of appetite, upset stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss.

If you take large doses for a long time, your doctor probably will decrease your dose gradually to allow your body to adjust before stopping the drug completely. Watch for these side effects if you are gradually decreasing your dose and after you stop taking the tablets or oral liquid, even if you switch to an inhalation corticosteroid medication. If these problems occur, call your doctor immediately. You may need to increase your dose of tablets or liquid temporarily or start taking them again.

 

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