Tianeptine sodium

SSRE Pharmaceutical Intermediates Tianeptine CAS 30123-17-2 Tianeptine Sodium for Antidepressant

 

Quick Details for TIANEPTINE SODIUM

Product Name: Tianeptine sodium salt
Synonyms: TIANEPTINE SODIUM;TIANEPTINE SODIUM SALT;sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate s,s-dioxide;7-[(3-Chloro-6,11-dihydro-6-methyldibenzo[c,f][1,2]thiazepin-11-yl)amino]heptanoic Acid S,S-Dioxide Sodium Salt;S-1574;Stablon;7-[(3-chloro-6,11-dihydro-6-methyl-dibenzo[c,f][1,2]thiazepine-11-yl)amino]heptanoic acid s,s dioxide sodium salt;Sodium 7-((3-chloro-6,11-dihydro-6-methyldibenzo(c,f)(1,2)thiazepin-11-yl)amino)heptanoate S,S-dioxide
CAS: 30123-17-2
MF: C21H24ClN2NaO4S
MW: 458.93
EINECS: 250-059-3
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles;Sulfur & Selenium Compounds;Stablon, Coaxil, Tatinol;API;Inhibitors
Melting point : 1800C
Storage temp. : Desiccate at RT
Chemical Properties : White to Yellowish Powder
Usage : Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant
Usage : Tianeptine (INN) (Stablon, Coaxil, Tatinol) is a selective serotonin reuptake enhancer (SSRE) drug used for treating major depressive episodes (mild, moderate, or severe).

 

Tianeptine sodium Description

Tianeptine (brand names Stablon, Coaxil, Tatinol, Tianeurax and Salymbra) is a drug used primarily in the treatment of major depressive disorder, although it may also be used to treat asthma or irritable bowel syndrome. Chemically it is a tricyclic antidepressant (TCA), but it has different pharmacological properties than typical TCAs as recent research suggests that tianeptine produces its antidepressant effects through indirect alteration of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity.

Tianeptine has antidepressant and anxiolytic (anti-anxiety) properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects,[citation needed] thus suggesting it is particularly suitable for use in the elderly and in those following alcohol withdrawal; such persons can be more sensitive to the adverse effects of psychotropic drugs. Recent results indicate possible anticonvulsant (anti-seizure) and analgesic (painkilling) activity of tianeptine via immediate or downstream modulation of adenosine A1 receptors (as the effects could be experimentally blocked by antagonists of this receptor).

 

Medical uses of Tianeptine sodium

Tianeptine shows efficacy against serious depressive episodes (major depression), comparable to amitriptyline, imipramine and fluoxetine, but with significantly fewer side effects. It was shown to be more effective than maprotiline in a group of people with co-existing depression and anxiety. Tianeptine also displays significant anxiolytic properties and is useful in treating a spectrum of anxiety disorders including panic disorder, as evidenced by a study in which those administered 35% CO2 gas (carbogen) on paroxetine or tianeptine therapy showed equivalent panic-blocking effects. Like many antidepressants (including bupropion, the selective serotonin reuptake inhibitors, the serotonin-norepinephrine reuptake inhibitors, moclobemide and numerous others) it may also have a beneficial effect on cognition in people with depression-induced cognitive dysfunction.

 

Tianeptine sodium Side effects

Compared to other TCAs it produces significantly fewer cardiovascular, anticholinergic (like dry mouth or constipation), sedative and appetite-stimulating effects. A recent review found that it was amongst the antidepressants most prone to causing hepatotoxicity (liver damage), although the evidence to support this concern was of limited quality. Although not well studied with tianeptine, it has been shown for tricyclic antidepressants that they may cause cardiac arrhythmias.

Atomoxetine hydrochloride

High Quality Depressive Disorder Pharmaceutical Powder Atomoxetine Hydrochloride CAS 82248-59-7

 

Product Name: Atomoxetine hydrochloride
Synonyms:ATOMOXETINE;ATOMOXETINE HCL;ATOMOXETINE HYDROCHLORIDE;METHYL-(3-PHENYL-3-O-TOLYLOXY-PROPYL)-AMINE HYDROCHLORIDE;(R)-N-METHYL-GAMMA-(2-METHYLPHENOXY)-BENZENEPROPANAMINE HYDROCHLORIDE;(r)-tomoxetine hydrochloride;TOMOXETINE HYDROCHLORIDE;Atomoxetine HCI
CAS: 82248-59-7
MF:C17H22ClNO
MW:291.82
EINECS:200-659-6
Product Categories:Active Pharmaceutical Ingredients;Heterocyclic Compounds;Chiral Reagents;Pharmacetes & Fine Chemicalsuticals;Inhibitors;Atomoxetine;Adrenoceptor;
STRATTERA;API
Melting point: 167-169°C
Fp: 9℃
Storage temp.: 2-8°C
Purity : 99%
Package : 1kg/25kg/package
Chemical Properties: White Solid
Uses: Psychotherapeutic, Anti Depressant
Uses: Norepinephrine reuptake inhibitor

 

Atomoxetine hydrochloride Description

Atomoxetine hydrochloride (atomoxetine) increased the risk of suicidal ideation in short-term studies in children or adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD). Anyone considering the use of atomoxetine hydrochloride in a child or adolescent must balance this risk with the clinical need. Co-morbidities occurring with ADHD may be associated with an increase in the risk of suicidal ideation and/or behavior. Patients who are started on therapy should be monitored closely for suicidality (suicidal thinking and behavior), clinical worsening, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Atomoxetine hydrochloride is approved for ADHD in pediatric and adult patients. Atomoxetine hydrochloride is not approved for major depressive disorder.

Pooled analyses of short-term (6 to 18 weeks) placebo-controlled trials of atomoxetine hydrochloride in children and adolescents (a total of 12 trials involving over 2200 patients, including 11 trials in ADHD and 1 trial in enuresis) have revealed a greater risk of suicidal ideation early during treatment in those receiving atomoxetine hydrochloride compared to placebo. The average risk of suicidal ideation in patients receiving atomoxetine hydrochloride was 0.4% (5/1357 patients), compared to none in placebo-treated patients (851 patients). No suicides occurred in these trials .

 

Uses

Atomoxetine is used to treat attention-deficit hyperactivity disorder (ADHD) as part of a total treatment plan, including psychological, social, and other treatments. It may help to increase the ability to pay attention, concentrate, stay focused, and stop fidgeting. It is thought to work by restoring the balance of certain natural substances (neurotransmitters) in the brain.

Armodafinil

Antidepressant Nootropics Analeptic Pharmaceutical CAS 112111-43-0 Armodafinil for Spontaneous Narcolepsy

 

Product Name: Armodafinil
Synonyms:2-[(R)-(Diphenylmethyl)sulfinyl]-acetamide
CAS: 112111-43-0
MF:C15H15NO2S
MW:273.354
Product Categories:Chiral Reagents;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
Melting point: 156-158℃
Density: 1.283
Chemical Properties: White Solid
Purity : 99%
Package : 1kg/25kg/package
Uses: Used for treatment of excessive sleepiness, a1-adrenoceptor agonist .
Uses: Analeptic. Has the role of arousal and cognitive improvement . For the treatment of spontaneous narcolepsy and narcolepsy drug .

 

Armodafinil Description

Armodafinil is the enantiopure compound of the eugeroic modafinil (Provigil).It consists of only the (R)-(−)-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc.and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.

Because armodafinil has a longer half-life than modafinil does, it may be more effective at improving wakefulness in patients with excessive daytime sleepiness.

 

Medical uses

Armodafinil is currently FDA-approved to treat excessive daytime sleepiness associated with obstructive sleep apnea, narcolepsy, and shift work disorder. It is commonly used off-label to treat attention deficit hyperactivity disorder, chronic fatigue syndrome, and major depressive disorder. It has been shown to improve vigilance in air traffic controllers.

Sleep disorders

Armodafinil is approved by the U.S. FDA for the treatment of narcolepsy and shift work sleep disorder, and as an adjuvant therapy for obstructive sleep apnea.For narcolepsy and obstructive sleep apnea, armodafinil is taken as a once daily 150 mg or 250 mg dose in the morning. For shift work sleep disorder, 150 mg of armodafinil are taken one hour prior to starting work. Slow dose titration is needed to mitigate some side effects.

Schizophrenia

In June, 2010, it was revealed that a phase II study of armodafinil as an adjunctive therapy in adults with schizophrenia had failed to meet the primary endpoints, and the clinical program was subsequently terminated.However, a study published later that year showed that schizophrenic patients treated with armodafinil showed fewer of the negative symptoms of schizophrenia.

Phenibut

Nootropic Supplement Antidepressant Drugs Phenibut

 

Product Name Phenibut

CAS Registry Number 1078-21-3

Molecular Formula C10H14ClNO2

Molecular Weight 215.68

Purity 99%

Grade Pharmaceutical Grade

Appearance White cystalline powder
Phenibut is a Russian Nootropic that is most commonly used for boosting mood, treating anxiety and helping to promote healthy sleep. Phenibut has a pretty complicated way that it interacts with the body, but interestingly, it is almost exactly the same way that alcohol works.

Phenibut is a calming, mood lifting, sociability enhancing, and potentially (in low serving sizes) nootropic supplement that acts as a GABA-B agonist to ease stress and support a positive, social mood. The primary benefits of Phenibut use also include pain-reduction, easing muscle tension and stress, and promotion of deep, restful sleep.Phenibut is one of the most effective and powerful amino acid supplements available.

 

WHAT ARE PHENIBUT HCL USES?
Phenibut HCL is a bit different than your typical nootropic compound. Although some anecdotal evidence shows potential for improved cognition, most people buy Phenibut HCL as it may provide mood support. Some Phenibut HCL benefits that many people experience include:
Calmness* – decreased stress and worrisome thoughtsRestfulness* – improved, restful sleepConfidence* – decreased feelings of shyness and social inhibition, more confidence on dates, at parties, and in public situations in general

 

PHENIBUT HCL BENEFITS
As a modified version of gamma-aminobutyric acid, Phenibut HCL offers many of the similar potential effects and benefits as GABA. GABA is naturally released by the brain to invoke feelings of calm and relaxation, but GABA cannot supplemented because the compound has trouble circulating from the blood to the brain or neurons on its own. Phenibut HCL has been shown to replicate many of GABA’s effects, activating the same receptors. This may result in relaxaton and a distinct calming effect.

Along with its potential mood support, Phenibut HCL may show evidence of improving mental performance and increasing cognitive abilities. According to some clinical studies, subjects taking Phenibut HCL showed improved brain function, particularly regarding communication between brain hemispheres. This form of brain communication is often associated with improved creativity, critical thinking, and problem solving abilities. Some limited research also suggests that Phenibut HCL may support memory and learning functions. Most importantly, Phenibut HCL may help you focus and channel your efforts into productive pursuits instead of getting caught up in negative feedback loops. Part of this comes from Phenibut HCL’s potential interactions with dopamine, a neurotransmitter involved in increasing motivation and personal drive.

Phenibut HCL may also be used to improve sleep quality by providing more internal calm, peace, and tranquility. Studies show that using Phenibut HCL may make it easier to fall asleep and allow for a more restful night’s sleep, possibly preventing insomnia and other sleep disorders. Accommodating good sleep has its own rewards for cognitive health. Studies show that Phenibut HCL may be effective in increasing REM sleep. While REM sleep is best known as the dream stage, it also plays a vital role in memory consolidation, learning, and maintaining basic functions throughout the brain and body. By extension, Phenibut HCL’s potential to provide sleep support may mean overall better cognitive performance across a wide variety of metrics.
Phenibut HCL’s potential anti-stress abilities may also make it an effective neuroprotection alternative. Research has shown that Phenibut HCL may prevent damage to neurons caused by high levels of stress hormones.

Alfuzosin Hydrochloride

Antihypertensive Pharmaceutical Raw Material Alfuzosin Hydrochloride CAS 81403-68-1 for BPH Treatment

 

Product Name : Alfuzosin hydrochloride
Synonyms:alfuzosinehydrochloride;SL-77,499-10;MITTOVAL;N-[3-[(4-AMINO-6,7-DIMETHOXY-2-QUINAZOLYNYL)METHYLAMINO]PROPYL]TETRAHYDRO-2-FURANCARBOXAMIDE;n-[3-[(4-amino-6,7-dimethoxy-2-quinazolynyl)methylamino]propyl]tetrahydro-2-furancarboxamide hydrochloride;XATRAL;URION;UROXANTRAL
CAS:81403-68-1
MF:C19H28ClN5O4
MW:425.91
Product Categories: APIs;Antihypertensive;Antihypertensive, Treatment of BPH;Intermediates & Fine Chemicals;Pharmaceuticals;Alfuzosin;Amines;Aromatics;Heterocycles;API;Uroxatral
Melting point 225°C
Storage temp. Store at RT
Chemical Properties : White to Off-White Solid
Uses : a-1- Adrenoceptor antagonist structurally similar to prozosin .
Uses : Antihypertensor;Alpha 1- adrenergic antagonist .
Uses : α1-Adrenoceptor antagonist structurally similar to Prozosin. Antihypertensive. Used in treatment of benign prostatic hypertrophy .

 

Alfuzosin Hydrochloride Description :

Alfuzosin is a selective α1 receptor blocker, belonging to the quinazoline derivatives, can relax the prostate, bladder neck and prostate urethral smooth muscle tension to reduce the resistance of urine flow, so that with the prostate Hypertrophy associated with urethral tension, increased resistance and pressure, bladder outlet obstruction and other symptoms can be alleviated. It has a rapid onset, has little effect on the cardiovascular system, and has no other BPH treatment of annoying sexual effects on the adverse effects.

Benign prostatic hyperplasia (BPH) is a common disease in middle-aged men. Prostatic hyperplasia obstruction of urine discharge, can cause irritation and obstructive urethral symptoms, the most common symptoms are: nocturia increased, day urine urgency, frequent urination, dysuria and so on. Many men over 70 years of age will experience moderate or severe urethral symptoms due to BPH. Although BPH itself is rarely life-threatening, but if not treated can cause irreversible damage to the bladder or kidney. Acute urinary retention is the most serious complication of BPH, and its clinical manifestations are characterized by sudden inability to urinate, accompanied by pain, if not treated in time, can be life-threatening.

Amoxazide hydrochloride oral absorption is good, 0.5-3 hours after serving the peak plasma concentration, bioavailability of 64%. In the therapeutic dose range, its pharmacokinetics are linear. Approximately 87% of the absorbed drug binds to plasma proteins. This product is mainly through the liver metabolism to eliminate, no active metabolites 75% -91% by the bile from the feces, 15% -30% by urine. About 11% of the original by urine excretion. Elimination of half-life of 4-8 hours. Its pharmacokinetic properties are not affected by the meal. In the elderly over 75 years of age, the goods absorb faster, higher plasma peak concentration, AUC is also higher than the young, and the distribution of volume can be reduced to eliminate half-life unchanged. In patients with renal insufficiency, the pharmacokinetic properties of alfuzosin did not change significantly. In patients with liver dysfunction, blood peak concentration, elimination half-life and AUC values ​​were increased, the free score also increased.

In addition, alfuzoside hydrochloride and similar prazosin and papaverine both the role of both block α1 receptor, but also direct relaxation of vascular smooth muscle, it has a good antihypertensive effect. For high blood pressure, oral 1 day 7.5 ~ 10mg, 3 times service. Note that alfuzosin hydrochloride can not be combined with calcium antagonists, alpha blockers.

Tianeptine Free Acid

Antidepressant Nootropic Tianeptine Free Acid CAS 66981-73-5 Tianeptine

 

Product Name : Tianeptine
Synonyms : TIANEPTINE;Tianeptine acid;COAXIL; Tianeptine Free Acid
CAS : 66981-73-5
MF : C21H25ClN2O4S
MW : 436.95
Product Categories : Heterocyclic Compounds;Intermediates & Fine Chemicals;Pharmaceuticals;Tianeptine Intermediates;API
Appearance : White powders
Package : 1kg/foil bag
Purity : 99%
Usage : Tricyclic compound with psychostimulant, anti-ulcer and anti-emetic properties. Antidepressant .

 

TIANEPTINE: WHAT IS TIANEPTINE ?

There are a number of drugs being tested and already on the marker that qualifies as nootropics, which are presented as “Smart Drugs”. Smart Drugs are believed to be low-risk and work to improve, enhance, or repair damage done to the brain via injury or disease. Most of the nootropics commonly discussed fall under the heading of Racetam, yet there are many that do not. Tianeptine is a nootropic, but it is classified as an antidepressant selective serotonin re-uptake enhancer (SSRE). Tianeptine is generally prescribed in doses broken up into individual doses of approximately 12 mg each, in the treatment of severe depression, anxiety disorders, bipolar disorder, and other “adjustment disorders”. In clinical trials, it has been determined that Tianeptine is as efficient as more common antidepressants, like amitriptyline and clomipramine. In addition, their effectiveness seems to require a smaller dose than the traditional antidepressants, as well (Wagstaff & et. al, 2001).

HOW DOES TIANEPTINE WORK ?

What makes Tianeptine so effective is that it reduces stress on the brain, both physical and mental. Tianeptine causes stress-induced alterations morphology and synaptic plasticity. As it alleviates stress, it also improved learning, brain cognition and memory, two things often diminished by serious depressive conditions. (Zoldaz & et. al, 2010). Like many drugs, there are still studies and concerns that the efficiency and effectiveness of Tianeptine as a whole is difficult to ascertain. After all, Tianeptine, like many drugs, can have a vastly distinct effect on some people and entirely different one on others. More studies are needed to determine if there is a universal dose or regiment that can produce absolute results.

 

TIANEPTINE DOSAGE

The recommended dosage of Tianeptine capsules is usually 12-36 mg per day, taken as 12mg individual dosages, one in the morning and one in the afternoon and a final in the evening time. This substance is sold in capsule, tablet and powder form.

 

DOES TIANEPTINE WORK ?

Tianeptine has several potential mechanisms of action from the actions on serotonin receptors as well as having possible neuro-protective activities. It also aids in reducing negative effects caused by stress in areas of the brain that are used for memorization and learning properties.

There are still many variables though that have to be looked at with improving cognitive abilities and improving overall mood. As a result, it is very hard to determine just how effective Tianeptine would be for a specific person. It all comes down to their own needs and current cognitive ability, mood, and lifestyle choices.

Sertraline hydrochloride

Antidepressant API Sertraline hydrochloride CAS 79559-97-0

Product Name: Sertraline hydrochloride
Synonyms:SERTRALINE HCL FORM I;SERTRALINE HCL FORM II;SERTRALINE HYDROCHLORIDE;SERTRALINE MANDELATE
CAS: 79559-97-0
MF: C17H18Cl3N
MW: 342.69
EINECS: 200-659-6
Product Categories: Pharmaceutical Intermediates;Active Pharmaceutical Ingredients;APIs;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Serotonin receptor;API;KETEK
Melting point : 246-249°C
Storage temp. : Desiccate at RT
Solubility : DMSO: ~26 mg/mL
Stability : Store in Freezer
Appearance : White powders
Purity : 98%
Package : 1kg/foil bag
Uses : A selective serotonin reuptake inhibitor. Used as an antidepressant and antibacterial .
SERTRALINE HYDROCHLORIDE Tablets : 25 mg, 50 mg, and 100 mg

 

Sertraline hydrochloride Description

Sertraline is the hydrochloride form of sertraliine. Sertraline belongs to the selective serotonin reuptake inhibitor (SSRI) class antidepressant drug. Sertraline is indicated for the treatment of major depressive disorder in adults as well as obsessive-compulsive disorder, post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder and social anxiety disorder occurring in both adults and children. Its exact mechanism of action is still not fully understand. But it is indicated that this drug can selectively inhibit the reuptake of serotonin at the presynaptic membrane, increasing serotonin levels in the synapses and enhancing serotonergic neurotransmission. This effect seems to be related to the antidepressant effect of sertraliine.