Letrozole

Product Name: Letrozole
Synonyms: 4,4′-(1H-1,2,4-TRIAZOL-1-YLMETHYLENE) BIS-BENZONITRILE;FEMARA;CGS-20267;LETROZOL;LETROZOLE;LetrozoleUsp28;Letrozole99%;CGS-20267, Femara
CAS: 112809-51-5
MF: C17H11N5
MW: 285.3
Product Categories: Anti-Cancer;Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;Letrozole;Antineoplastic;All Inhibitors;anti-neoplastic;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API’s;APIs;Antibiotics;Aromatics;Heterocycles;ELOXATIN;Anti-cancer&immunity
mp 181-183°C
storage temp. -20°C Freezer
Chemical Properties white to light yellow crystal
Usage A nonsteroidal aromatase inhibitor structurally related to Fadrozole. Antineoplastic.Pyrrole type aromatase inhibitors. For the treatment of breast cancer.

Anastrozole

Product Name: Anastrozole
Synonyms: ICI-D-1033;ARIMIDEX;1-[3,5-DI-(1-METHYL-1-CYANO)-ETHYL]-BENZYL-1,2,4-TRIAZOLE;ANASTRAZOLE;ANASTROZOLE;tetramethyl-5-(1h-1,2,4-triazol-1ylmethyl) 1,3-benzenediacetionitrile;ZD-1033;1,3-benzenediacetonitrile,alpha,alpha,alpha’,alpha’-tetramethyl-5-(1h-1,2,4-t
CAS: 120511-73-1
MF: C17H19N5
MW: 293.37
Product Categories: Active Pharmaceutical Ingredients;Antineoplastic;All Inhibitors;anti-neoplastic;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Anastrozole;API
mp 81-82°C
storage temp. Store at RT
HS Code 29339980
Chemical Properties : Crystalline Solid
Usage : An aromatase inhibitor. Used as an antineoplastic.
antiseptic, spermaticide

Biological Activity : Potent and highly selective aromatase (CYP19) inhibitor (IC 50 = 15nM) that has no discernible effect on adrenocorticoid hormone synthesis. Reduces plasma estrogen levels and exhibits antitumor activity in vivo . Orally active.

Application:
The third generation of aromatase inhibitors. For the treatment of the patients with advanced breast cancer in postmenopausal.
Treatment of breast cancer.

The third generation of aromatase inhibitors. For the treatment of the patients with advanced breast cancer in postmenopausal. Three azole aromatase inhibitors are potent selective, it can inhibit the cytochrome P-450 dependent aromatase thereby blocking the biosynthesis of estrogen and estrogen, the main factors to stimulate the growth of breast cancer cells. The treatment of breast cancer, especially suitable for those who use hormonal adjuvant therapy after relapse after menopause women with advanced breast cancer.

Raw materials : Ethyl acetate–>N,N-Dimethylformamide–>PETROLEUM ETHER–>Sodium hydride –>Carbon tetrachloride–>Iodomethane–>N-Bromosuccinimide–>1,2,4-Triazole–>1,2,4-Triazolylsodium–>5-Methyl-1,3-benzenediacetonitrile

Letrozole

Natural Anti Estrogen Steroid Letrazole 112809-51-5 Femara White Powder for Breast Cancer Treatment

Quick Details for Letrozole Femara

Product name : Letrozole
CAS : 112809-51-5
Synonyms : FEMARA;CGS-20267;LETROZOL;LETROZOLE;LetrozoleUsp28;Letrozole99%;CGS-20267, Femara
Purity : 99%
Appearance : White or light yellow crystal
Molecular Formula : C17H11N5
Molecular Weight : 285.31
Usage : Used as API in Treatment of breast cancer .

Letrozole Femara Description

Letrazole(Femara) is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letrozole is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Letrozole decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional .

This medication may also be used to treat infertility in women .

Letrozole(Femara) was first developed in an effort to combat breast cancer in post-menopausal women. In fact, it would prove to be virtually identical to the already popular AI in Arimidex (Anastrozole). While intended for breast cancer treatment, like many AI’s, it has found a welcomed home among anabolic steroid users. Letrozole is one of the most commonly used anti-estrogens among steroid users duringsteroid use to combat possible estrogenic related side effects. It is so effective as an anti-estrogen in this regard many anabolic steroidshave effectively reversed gynecomastia symptoms with Letrozole.

Letrozole lowers the levels of the female sex hormone oestrogen in the body. Oestrogen stimulates some breast cancers to grow. These breast cancers are called hormone sensitive or hormone receptor positive. Letrozole can stop or slow the growth of these cancers. It can also reduce the chance of a breast cancer coming back after surgery.

Letrozole only works in women who have had their menopause. It is a type of drug called an aromatase inhibitor. After the menopause, women don’t produce oestrogen from their ovaries. But they still produce a small amount by using an enzyme called aromatase which turns other sex hormones called androgens into oestrogen. This change happens mainly in fatty tissue, muscle and the skin. Aromatase inhibitors block aromatase so that it can’t change the androgen into oestrogen.

Letrazole Application

1) Primarily treating certain kinds of breast cancer in women past menopause. It may also be used for other conditions as determined by your doctor.

2) Letrozole is an aromatase inhibitor. It works by reducing the total amount of estrogen produced primarily in the body. This helps to starve cancer cells by.

3) The anti-estrogen action of letrozole has been shown to be useful in pretreatment for termination of pregnancy, in combination with misoprostol. It can be used in place of mifepristone, which is expensive and unavailable in many countries.

4) Letrozole is sometimes used as a treatment for gynecomastia, although it is probably most effective at this if caught in an early stage (such as in users of anabolic steroids) .

5) Some studies have shown that letrozole can be used to promote spermatogenesis in male patients suffering from nonobstructive azoospermia.

6) Letrozole has also been shown to delay the fusing of the growth plates in mice.When used in combination with growth hormone, letrozole has been shown effective in one adolescent boy with a short stature .

7) Letrozole has also been used to treat endometriosis.

Femara and Letrozole Dosing

The most common dose of Femara is 2.5 mg per day on days five through nine of the menstrual cycleSometimes it is given in higher doses of 5 mg or 7.5 mg per day .

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Anastrozole

Anti-estrogen Anastrozole 120511-73-1 Arimidex Powder To Inhibition Of Breast Tumor

Quick Details for Anastrozole Arimidex

Product name : Anastrozole
Alias : Arimidex ,Tetramethyl-5-(1H-1,2,4-triazol-1ylmethyl)1,3-benzenediacetionitrile
CAS NO.: 120511-73-1
Assay : 98%~102%
Appearance : White crystalline powder
Active life cycle : 6 hours
MF : C17H19N5
MW : 293.37
Grade : Pharmaceutical Grade
Storage : Shading , confined preservation .
Usage : Anastrozole is a potent non-steroidal aromatase inhibitors , which lead the decrease of plasma level of estrogen, inhibited the growth of breast cancer. For the treatment of advanced breast cancer in postmenopausal women patients .

Anastrozole Arimidex Description

Anastrozole is a drug indicated in the treatment of breast cancer in post-menopausal women. It is used both in adjuvant therapy (i.e. following surgery) and in metastatic breast cancer.

Many breast cancers also contain aromatase; the importance of tumor-generated estrogens is uncertain. Treatment of breast cancer has included efforts to decrease estrogen levels by ovariectomy premenopausally and by use of anti-estrogens and progestational agents both pre- and post-menopausally, and these interventions lead to decreased tumor mass or delayed progression of tumor growth in some women. Anastrozole is a potent and selective non-steroidal aromatase inhibitor. It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone .

Anastrozole Arimidex Application

In studies that have been done, Arimidex has been shown to reduce estrogen in the body by roughly 50%. This is a good balance for bodybuilders , because some estrogen is needed in order for the full anabolic benefits of the steroids being taken to be achieved. These results are typically the same with a dosage of .5 mg a day as they are with a dosage of 1 mg a day, meaning that in most cases, a half tablet a day will be sufficient for estrogen control throughout cycle.

Anastrozole will begin taking it the day they start their cycle, Anastrozole will run it throughout the duration of steroid administration. Anastrozole is also important to point out GP Anastrozole’s ability to increase testosterone in the body. Some studies have shown that natural testosterone levels have increases as much as 60% after the use of this substance for 7 days. Because of this, bodybuilders find Anastrozole extremely effective during PCT where as they are trying to elevate natural levels as much as possible in order to avoid a post cycle “crash”.

Although Arimidex does increase testosterone levels slightly in the body, it is more often used in conjunction with other steroids to lower estrogen in the body. Many anabolic steroids will convert, or aromatize, in the body into estrogen, which causes many of the unwanted side effects like bloating and acne. Arimidex is one of the best compounds to lower the aromatizing effect of steroids.

Anastrozole Arimidex Dosage

Most men will find 0.5mg every other day to be a good starting point while on cycle if it is needed for side-effect prevention with 1mg every other day generally being the most anyone will ever need for this purpose .

The same dose can be applied in physique sport competition, most notably bodybuilding; it is very common for many bodybuilders to supplement with Arimidex for 12-16 weeks leading up to a competition at a dose of 1mg every other day.

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Exemestane

High Quality Pharmaceutical Chemicals Exemestane 107868-30-4 Aromasin Raw Steroids

Quick Details for Exemestane Aromasin

Product Name : Exemestane Aromasin
CAS : 107868-30-4
Molecular Formula : C20H24O2
Molecular Weight : 296.40
Assay : 98%min
Grade : Pharmaceutical Grade
Appearance : White Or Almost White Crystalline Powder
Usage : For treatment Exemestane Aromasin use .

Exemestane Aromasin Effect

Aromasin is a suicidal aromatase inhibitor (AI), meaning it permanently disables the aromatase enzyme once it binds to it. In plain English, Aromasin will prevent the currently bound enzymes from rebounding, which is what separates this drug from letrozole or arimidex. When you use other AI’s, they temporarily stop estrogen from aromatizing, but when you stop taking them those same enzymes can rebound causing what is known as ‘estrogen rebound’. This explains why some anabolic steroid users experience gynecomastia (bitch tits) after cycle when using other AI’s. Studies on breast cancer patients have shown aromasin reduced estrogen levels up to 85%.

Athletes commonly buy Aromasin to aid in their performance enhancement in conjunction with anabolic steroids. As an aromatase inhibitor Aromasin reduces the amount of estrogen in the body and this is precisely the reason any athlete will buy Aromasin. Make no mistake, Estrogen is essential to our overall well-being but this hormone is also damaging to a physique when levels become too high.When our estrogen levels are too high we will have difficulty in maintaining a lean and hard physique and if were using anabolic steroids a host of negative side-effects can rear their heads.This is why many steroid users buy Aromasin and with proper use they eliminate the potential problems associated with estrogen build up.

Aromasin Dosage

This is dependent on the individual and, also, the amount of aromatizing compounds the person is running. Generally, a good starting dose is 12.5mg ED (every day) or 25mg EOD (every other day). The user must utilize blood work to see how their body is reacting at the starting dosage they choose and then adjust as needed. Experienced anabolic steroid users will usually find a dose they like and stick to it with no problems. As I said already, if you start noticing joint issues then the dose should be lowered; on the other hand, if you start noticing any estrogen related sides, such as puffy or sensitive breasts or water retention, it’s time to increase the dosage .

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Toremifene Citrate

Factory Supply Oral SERM Fareston 89778-27-8 Toremifene Citrate

Quick Details for Toremifene Citrate

Product Name : Toremifene Citrate
Trade name : Fareston
CAS Registry Number : 89778-27-8
Molecular Formula : C26H28ClNO.C6H8O7
Molecular Weight : 598.09
Purity : 99%
Grade : Pharmaceutical Grade
Appearance : White cystalline powder
Usage : SERM for treating breast cancer in postmenopausal women .

Toremifene Citrate Effect

Toremifene citrate is an oral selective estrogen receptor modulator (SERM) which helps oppose the actions of estrogen in the body. Licensed in the United States under the brand name Fareston , toremifene citrate is FDA-approved for use in advanced (metastatic) breast cancer. It is also being evaluated for prevention of prostate cancer under the brand name Acapodene.

It has already been covered that Toremifene is a SERM, and serves to block Estrogen at various receptor sites in certain tissues within the body (breast tissue in particular). As a layman explanation, Toremifene pretends to be a ‘fake’ Estrogen that occupies Estrogen receptors within breast tissue. With these receptors occupied by Toremifene, real Estrogen cannot perform their jobs there. Toremifene does not reduce total blood plasma levels of Estrogen. In addition to being antagonistic to Estrogen receptors in breast tissue, it is also antagonistic to Estrogen at the hypothalamus gland (this essentially ‘tricks’ the hypothalamus into thinking there is little or no circulating Estrogen levels in the body, causing it to increase its manufacture of Testosterone so that it can utilize aromatization to restore these levels.

Toremifene Citrate exerts its effects by antagonizing the estrogen receptor in some tissues, and agonizing it in others. In this way, certain estrogenic pathways are activated and others are blockaded. It seems to exert estrogenic effects on blood lipids, reducing LDL and total cholesterol, as well as estrogenic effects on bone, improving density. It would also appear to exert anti-estrogenic effects in breast tissue, displacing the traditional effects of estrogen, effectively helping prevent breast cancer in postmenopausal women .

Fareston Administration

In the fight against breast cancer, standard Fareston doses will normally be 60mg per day. The total duration of use is unpredictable and will be based on patient need. It’s not uncommon for treatment to last a year or two and then AI’s to be added if needed. Once the cancer is in remission, compounds like Fareston are commonly used to support the improved state .

For the anabolic steroid user combating gynecomastia, standard Fareston doses will fall in the 30-60mg per day range and will work very well for most men. If this is not enough protection, while you could try increasing the dose your best bet would be to move to AI use. You will find Fareston works very well in combating gynecomastia due to the use of any testosterone, Dianabol and Anadrol. You will also find it works well with Equipoise and Deca Durabolin. However, as Deca Durabolin is also a progestin, men who are very sensitive to that hormone may need an AI. The same can be said of the Trenbolone hormone. Trenbolone does not aromatize, but it is a progestin. Further, the use of an aromatizing steroid with a compound like Trenbolone can increase the risk of gynecomastia in some men. While many will not need gynecomastia protection due to progestins and will get by with SERM’s to combat aromatase, some sensitive men will need an AI. Regardless, if Fareston works for you it will cover the entire breadth of the cycle from start to finish .

 

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Clomifene Citrate

Steroid Supplemnents Post Cycle Therapy Clomifene Citrate 50-41-9 Clomid

Quick Details for Clomifene Citrate Clomid

 

Product Name : Clomifene Citrate
Alias : Clomid
CAS Registry Number : 50-41-9
EINECS : 200-035-3
Molecular Formula : C32H36ClNO8
Molecular Weight : 598.08
Purity : 99%
Grade : Pharmaceutical Grade
Appearance : White cystalline powder
Usage : SERM for bodybuilding .

Clomifene Effect

Clomid , or Clomiphene Citrate, is a SERM (selective estrogen receptor modulator), so it’s in the same grouping as tamoxifen (nolvadex). It is the most widely prescribed drug for ovulation induction, which is useful for those who are infertile.

Male bodybuilders who cycle anabolic androgenic steroids (AAS) have found that the same mechanisms of increased LH (luteinizing hormone) can be taken advantage of to increase total testosterone levels. This is why clomid is popular in post cycle therapy (PCT) among those who cycle anabolic steroids. Since clomid has ability to bind to the estrogen receptors, much like nolvadex, in male users who run estrogenic compounds such as testosterone, dianabol, and deca durabolin, it can be used as gynecomastia treatment (anti-gyno). However, clomid is a fairly weak anti-gyno aid, and is rarely used for that purpose. Due to its ability to boost testosterone levels, it has been put on the WADA (world anti-doping agency) list of illegal doping agents in sport.

Clomid PCT

When a steroid user runs a cycle their HPTA becomes suppressed; as a result, their bodies LH and FSH drop to almost zero (0) and their body stops producing testosterone. Their testicles typically will shrink as the body realizes there are too many hormones present and it’s not necessary to produce more. So, when you come off a cycle it’s important to run a PCT (post cycle therapy) to help recover the body’s HPTA.

Clomid stimulates the hypophysis to release more gonadotropins. Gonadotropins are protein hormones that are secreted by gonadotrope cells of the pituitary gland and stimulate faster and higher release of follicle stimulating hormone (FSH) and luteinizing hormone (LH). When an increase in gonadotropins happens, the rise in LH will spike up the total testosterone levels allowing the user to artificially maintain high testosterone levels until their own body is able to recover, thus maintaining gains.

Clomid Dosage

If you’re going to put it into your body from medicine to hormones or in this case a SERM you are going to want to know the proper dose; after all, without this information it’s unlikely you’re going to be able to use it correctly. Like many things a Clomid dosage can vary quite dramatically but one thing is for certain the average Clomid dosage among many performance enhancers is far too low. It is very common to see a Clomid dosage of 50mg per day for Post Cycle therapy (PCT) purposes and while there is a use for this dose during PCT it should be noted, 50mg of this SERM is about the equivalent of 10mg of Nolvadex .

 

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