Phenylbutazone Active Pharmaceutical Ingredients 50-33-9 Anti-inflammatory Compound

Phenylbutazone Active Pharmaceutical Ingredients 50-33-9 Anti-inflammatory Compound

 

Quick Details for Phenylbutazone

Product Name: Phenylbutazone
Synonyms: PHENYLBUTAZONE;1,2-Diphenyl-2,3-dioxo-4-N-butylpyrazoline;1,2-Diphenyl-3,5-dioxo-4-butylpyrazolidine;1,2-Diphenyl-4-butyl-3,5-dioxopyrazolidine;1,2-Diphenyl-4-butyl-3,5-pyrazolidinedione;3,5-dioxe-4buty-1,diphenyl-pyrazolidine;3,5-dioxo01,2-diphenyl-4-m-butyl-pyrazolidine;3,5-Dioxo-1,2-diphenyl-4-N-butyl-pyrazolidin
CAS: 50-33-9
MF: C19H20N2O2
MW: 308.37
EINECS: 200-029-0
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles;Inhibitors;API;AZOLID
Melting point : 104-107 °C
Storage temp. : -20°C Freezer
Chemical Properties : Off-Whtie Solid
Usage : A non-steroidal anti-inflammatory compound. An inhibitor of cyclooxygenase that is also a substrate for peroxidation by cyclooxygenase
Usage : For the treatment of backache and ankylosing spondylitis .

 

Phenylbutazone Description

Phenylbutazone, often referred to as “bute,” is a nonsteroidal anti-inflammatory drug (NSAID) for the short-term treatment of pain and fever in animals.

In the United States and United Kingdom it is no longer approved for human use (except for ankylosing spondylitis, because no other treatment is available), as it can cause severe adverse effects such as suppression of white blood cell production and aplastic anemia. This drug was implicated in the 2013 meat adulteration scandal. Positive phenylbutazone tests in horse meat were uncommon in the UK, however.

 

Phenylbutazone Uses

In humans

Phenylbutazone was originally made available for use in humans for the treatment of rheumatoid arthritis and gout in 1949. However, It is no longer approved, and therefore not marketed, for any human use in the United States. In the UK it is used to treat ankylosing spondylitis, but only when other therapies are unsuitable.

In horses

Phenylbutazone is the most commonly used NSAID for horses in the United States. It is used for the following purposes:

Analgesia: It is used for pain relief from infections and musculoskeletal disorders, including sprains, overuse injuries, tendinitis, arthralgias, arthritis, and laminitis. Like other NSAIDs, it acts directly on musculoskeletal tissue to control inflammation, thereby reducing secondary inflammatory damage, alleviating pain, and restoring range of motion. It does not cure musculoskeletal ailments or work well on colic pain.

Antipyresis: It is used for reduction of fevers. Its antipyretic qualities may mask other symptoms; therefore, it should not be administered for this purpose unless a veterinarian has concluded the horse would not be able to eat or drink without its use or that the fever might hinder the horse’s recovery.

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