Antibacterial Pharmaceutical Raw Materials Amikacin Disulfate Salt CAS 39831-55-5
Quick Details for Amikacin disulfate salt
Product Name: Amikacin disulfate salt
Synonyms: AMIKACIN SULPHATE;AMIKACIN DISULFATE;AMIKACIN DISULFATE SALT;AMIKACIN SULFATE;(s)-ysulfate(1:2)(salt);antibioticbb-k8sulfate;y-alpha-d-glucopyranosyl-(1-4))-n(sup1)-(4-amino-2-hydroxy-1-oxobutyl)-2-deox;amikacin bis(sulphate)
Product Categories: Active Pharmaceutical Ingredients;Amines;Intermediates & Fine Chemicals;Oligosaccharides;Pharmaceuticals;AMIKIN;Antibiotics;Inhibitors
Melting point : 220-230 C
Storage temp. : 2-8°C
Solubility H2O: 50 mg/mL, clear, colorless
Chemical Properties : White Solid
Usage : Analgesic
Usage : Semisynthetic aminoglycoside antibiotic derived from Kanamycin A . Antibacterial .
Amikacin disulfate salt Description
Amikacin is an antibiotic used for a number of bacterial infections. This includes joint infections, intraabdominal infections, meningitis, pneumonia, sepsis, and urinary tract infections. It is also used for the treatment of multidrug-resistant tuberculosis. It is used either by injection into a vein or muscle.
Common side effects include hearing loss, balance problems, and kidney problems. Other side effects include paralysis resulting in the inability to breathe. If used during pregnancy it may cause permanent deafness in the baby. Amikacin is in the aminoglycoside family of medications. It works by blocking the function of the bacteria’s 30S ribosomal subunit, making it unable to make protein.
Amikacin was patented in 1971 and came into commercial use in 1976. It is on the World Health Organization’s List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is 13.80 to 130.50 USD for a month. In the United States a typical course of treatment costs 25 to 50 USD. It is made from kanamycin .
Amikacin disulfate salt Medical uses
Amikacin is most often used for treating severe, hospital-acquired infections with multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter. Serratia marcescens and Providencia stuartii are also included in the spectrum. Amikacin can also be used to treat non-tubercular mycobacterial infections and tuberculosis (if caused by sensitive strains) when first-line drugs fail to control the infection .
Amikacin may be combined with a beta-lactam antibiotic for empiric therapy for people with neutropenia and fever .
Liposomal amikacin for inhalation is currently in late stage clinical trials for the treatment of respiratory diseases, such as cystic fibrosis, Pseudomonas aeruginosa, non-tubercular mycobacterial infections and bronchiectasis .