Mifepristone

Natural Progesterone Hormone 84371-65-3 Mifepristone Used In Combination With Misoprostol

 

Quick Details for Mifepristone

Product Name : Mifepristone
Synonyms : 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-9-dien-3-one;11beta-[4-(n,n-dimethylamino)phenyl]-17alpha-(prop-1-ynyl)-delta4,9-estradiene;17-beta)-(11-bet;17beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-(11bet;17-beta-hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oest;-17beta-ol-3-one;4,9-dien-3-one;r38486
CAS : 84371-65-3
MF : C29H35NO2
MW : 429.59
Product Categories : Steroids;Hormone;Acetylenes;Biochemistry;Functionalized Acetylenes;Hydroxyketosteroids;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Intracellular receptor;Nuclear Receptors;Steroid and Hormone;API;Hormone Drugs
Melting point : 195-198°C
Storage temp. : 2-8°C
Chemical Properties : Pale Yellow Solid
Usage : A progesterone receptor antagonist with partial agonist activity. Abortifacient.
Usage : glutamate uptake inhibitor, AMPA blocker .

 

Mifepristone Description

Mifepristone is used alone or in combination with misoprostol (Cytotec) to end an early pregnancy. Early pregnancy means it has been 49 days or less since your last menstrual period began. Mifepristone is in a class of medications called antiprogestational steroids. It works by blocking the activity of progesterone, a substance your body makes to help continue pregnancy.

 

Mifepristone Applications

Mifepristone is also available as another product, which is used to control hyperglycemia in people with a certain type of Cushing’s Syndrome in which the body makes too much of the hormone cortisol. This monograph only gives information about mifepristone, which is used alone or in combination with another medication to end an early pregnancy. If you are using mifepristone to control hyperglycemia caused by Cushing’s syndrome, read the monograph entitled mifepristone that has been written about this product.

Mifepristone comes as a tablet to take by mouth. You will take one tablet of mifepristone once on the first day. Within 24 to 48 hours after taking mifepristone, you will apply four tablets in total of another medication called misoprostol buccally by placing two tablets in each cheek pouch for 30 minutes, then swallowing the remaining content with water or another liquid. Make sure that you are in an appropriate location when you take misoprostol because vaginal bleeding, cramps, nausea, and diarrhea usually begins within 2 to 24 hours after taking it but could begin within 2 hours. Vaginal bleeding or spotting usually lasts for 9 to 16 days but can last for 30 days or longer.

 

Mifepristone is used for emergency contraception

Mifepristone is a progesterone receptor antagonist used as an abortifacient in the first months of pregnancy, and in smaller doses as an emergency contraceptive. It is also a powerful glucocorticoid receptor antagonist, and has occasionally been used in refractory Cushing’s syndrome (due to ectopic/neoplastic ACTH/cortisol secretion).

Mifepristone was the first antiprogestin to be developed and it has been evaluated extensively for its use as an abortifacient.

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