Biological Buffers Pharmaceutical Raw Materials MES sodium salt CAS 71119-23-8
Product Name: MES sodium salt
Synonyms: SODIUM 2-MORPHOLINOETHANESULFONATE;sodium 4-morpholin-1-ylethylsulphonate;4-morpholineethanesulfonic acid sodium salt;2-MORPHOLINOETHANESULFONIC ACID SODIUM SALT;2-(N-MORPHOLINO)ETHANESULFONIC ACID, NA;2-(N-MORPHOLINO)ETHANESULFONIC ACID SODIUM SALT;MES SODIUM SALT;Methyl ethane sulfonic acid
Product Categories: Pharmaceutical Raw Materials
Storage temp. : Store at RT.
Solubility H2O: 0.5 g/mL, clear, colorless
Chemical Properties : White powder
MES sodium salt Description
MES is the common name for the compound 2-(N-morpholino)ethanesulfonic acid. Its chemical structure contains a morpholine ring. It has a molecular weight of 195.2 and the chemical formula is C6H13NO4S. Synonyms include: 2-morpholinoethanesulfonic acid; 2-(4-morpholino)ethanesulfonic acid; 2-(N-morpholino)ethanesulfonic acid; 2-(4-morpholino)ethanesulfonic acid; MES; MES hydrate; and morpholine-4-ethanesulfonic acid hydrate. MOPS is a similar pH buffering compound which contains a propanesulfonic moiety instead of an ethanesulfonic one.
MES sodium salt Applications
MES is used as a buffering agent in biology and biochemistry. It has pKa value of 6.15 at 20 °C. The pH (and pKa at ionic strength I≠0) of the buffer solution changes with concentration and temperature, and this effect may be predicted using online calculators. MES is highly soluble in water. The melting point is approx. 300 °C.
MES was developed as one of Good’s buffers in the 1960s. These buffers were developed with the following criteria in mind: midrange pKa, maximum water solubility and minimum solubility in all other solvents, minimal salt effects, minimal change in pKa with temperature, chemically and enzymatically stable, minimal absorption in visible or UV spectral range and reasonably easily synthesized. MES is also useful as a non-coordinating buffer in chemistry involving metal ions, as many common buffers (e.g. phosphate and acetate) readily form coordination complexes. MES only weakly binds Ca, Mg, Mn, and it has negligible binding with Cu(II) .