Antiinflammatory Glucocorticoid Betamethasone Sodium Phosphate CAS 151-73-5
Quick Details for Betamethasone sodium phosphate
Product Name: Betamethasone sodium phosphate
Synonyms: 20-dione,9-fluoro-11-beta,17,21-trihydroxy-16-beta-methyl-pregna-4-diene-3;21-(dihydrogenphosphate),disodiumsalt;bentelan;betamethasonedisodiumphosphate;BETMETHASONE DISODIUM PHOSPHATE;betnesol;BETAMETHASONE 21-DISODIUM PHOSPHATE;betamethasone 21-phosphate disodium
Product Categories: Betamethasone;Hormones;Steroid Hormones;Intermediates & Fine Chemicals;Pharmaceuticals;Phosphorylating and Phosphitylating Agents;Steroids;CELESTONE
Appearance : White crystalline powders
Usage A Betamethasone
Usage antiinflammatory, glucocorticoid
Usage Nasal, Ophthalmic, Oral, Parenteral.
Betamethasone sodium phosphate Description
Betamethasone Sodium Phosphate is the disodium salt of the 21-phosphate ester of betamethasone, a synthetic glucocorticoid with metabolic, immunosuppressive and anti-inflammatory actions. Betamethasone sodium phosphate binds to specific intracellular glucocorticoid receptors and subsequently binds to DNA to modify gene expression. The synthesis of certain anti-inflammatory proteins is induced while the synthesis of certain inflammatory mediators is inhibited. As a result, there is an overall reduction in chronic inflammation and autoimmune reactions .
Betamethasone sodium phosphate Application
Glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids that are readily absorbed from the gastrointestinal tract.
Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their anti-inflammatory effects in disorders of many organ systems. A derivative of prednisolone, betamethasone has a 16β-methyl group that enhances the anti-inflammatory action of the molecule and reduces the sodium- and water-retaining properties of the fluorine atom bound at carbon 9.
Betamethasone sodium phosphate, a soluble ester, provides prompt activity, while betamethasone acetate is only slightly soluble and affords sustained activity.