Antihypertensive Pharmaceutical Raw Materials Losartan Potassium CAS 124750-99-8
Quick Details for Losartan potassium
Product Name: Losartan potassium
Synonyms: 2-BUTYL-4-CHLORO-1-[[2′-(1H-TETRAZOL-5YL)[1,1′-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL;2-butyl-4-chloro-1-[[2′-(1h-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol monopotassium salt;2-BUTYL-4-CHLORO-1-[[2′-(1H-TETRAZOLE-5-YL)[1,1′-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL, POTASSIUM SALT;COZAAR;DUP 753;LOSARTAN MONOPOTASSIUM SALT;LOSARTAN POTASSIUM;LOSARTAN POTASSIUM SALT
Product Categories: Hypertension;Intermediates & Fine Chemicals;Pharmaceuticals;Losartan;APIS;Aromatics;Heterocycles;API Reference Standard;COZAAR;Cardiovascular APIs;API
Melting point : 263-265°C
Storage temp. : Desiccate at RT
Chemical Properties : White to Off-White Crystalline Powder
Usage : A nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
Usage : antihypertensive, AT1 angiotensin II antagonist
Usage : Coronary vasodilator used in the diagnosis of coronary heart disease (adenosine A2A agonist).
Losartan Potassium Medical uses
As with all angiotensin II type 1 receptor (AT1) antagonists, losartan is indicated for the treatment of hypertension. It may also delay progression of diabetic nephropathy and is associated with a positive clinical outcome in that regard. It is a suitable pharmacological agent for the reduction of renal disease progression in patients with type 2 diabetes, hypertension, and microalbuminuria (>30 mg/24 hours) or proteinuria (>900 mg/24 hours).
Although clinical evidence shows calcium channel blockers and thiazide-type diuretics are preferred first-line treatments for most patients (due to both efficacy and cost), an angiotensin II receptor antagonist such as losartan is recommended as first-line treatment in patients under the age of 55 who cannot tolerate an ACE inhibitor. The LIFE study demonstrated losartan was significantly superior to atenolol in the primary prevention of adverse cardiovascular events (myocardial infarction or stroke), with a significant reduction in cardiovascular morbidity and mortality for a comparable reduction in blood pressure. A study hints that losartan has a beneficial effect on mitochondria by reversing age related dysfunction in maintaining normal blood pressure and cellular energy usage. The maximal effects on blood pressure usually occur within 3-6 weeks of starting losartan.
Losartan is also available as hydrochlorothiazide/losartan, a combination drug with a low-dose thiazide diuretic to achieve an additive antihypertensive effect.