Antifungal Pharmaceutical Raw Materials GRISEOFULVIN CAS 126-07-8

Antifungal Pharmaceutical Raw Materials GRISEOFULVIN CAS 126-07-8

 

Quick Details for GRISEOFULVIN

Product Name: GRISEOFULVIN
Synonyms: (+)-GRISEOFULVIN;GRISEOFULVIN;[2S-TRANS]-7-CHLORO-2,4,6-TRIMETHOXY-6′-METHYLSPIRO[BENZOFURAN-2(3H), 1′(2)-CYCLOHEXANE]-3,4′-DIONE;(2S)-TRANS-7-CHLORO-2′,4,6-TRIMETHOXY-6′-METHYLSPIRO(BENZOFURAN-2[3H],1′-[2]CYCLOHEXENE)-3,4′-DIONE;7-CHLORO-2′,4,6-TRIMETHOXY-6′-METHYL-, (1’S-TRANS)-SPIRO(BENZOFURAN-2(3H),1′-(2)CYCLOHEXENE)-3,4′-DIONE;(+)-griseofulvi;(2s-trans)-7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3h),1’-[2]cy;(2s-trans)-xy-6’-methyl
CAS: 126-07-8
MF: C17H17ClO6
MW: 352.77
EINECS: 204-767-4
Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Antifungal;Aromatics;Chiral Reagents;VERELAN;Inhibitors
Melting point : 218-220 °C(lit.)
Alpha : 354 º (c=1, dimethylform)
Storage temp. : −20°C
Water Solubility  : practically insoluble
Chemical Properties : Crystalline Solid
Usage : adrenegic blocker, Ca channel blocker, coronary vasodilator, antiarrhythmic .
Usage : antifungal, inhibits mitosis in metaphase .
Usage : Griseofulvin is a spirobenzofuran produced by a number of Penicillium species, first isolated in the 1930s by Raistrick’s group. Griseofulvin is a selective antifungal agent used to treat skin infections in animals and humans. Griseofulvin acts by binding to fungal tubulin and inhibiting the mitotic spindle. Griseofulvin’s ability to bind to keratin is considered an important aspect of the metabolite’s access to dermatophytic fungi. More recently, griseofulvin has become an important phenotypic marker in Penicillium taxonomy.
Usage : It is an antifungal drug. It is used both in animal and in humans, to treat rigworm infections of the skin and nails. It is derived from the mold Penicillium griseofulvum .

 

GRISEOFULVIN Description

Griseofulvin is a non-polyene class antifungal antibiotics; it can strongly inhibit the mitosis of fungal cell and interfere with the fungal DNA synthesis; it can also bind to tubulin to prevent fungal cell division. It has been applied to clinical medicine since 1958 and has currently been widely used for treating the fungal infections of the skin and the stratum corneum with strong inhibitory effects on Trichophyton rubrum and Trichophyton tonsorans, etc. Griseofulvin is not only a widely used antibiotic for clinical treatment of fungal infections of the skin and cuticle, but also applied in agriculture for prevention and treatment of fungal diseases; for example, it has a special efficacy on treating a kind of candidiasis in apple which can cause infection during pollination.

 

GRISEOFULVIN Pharmacological Effects

In medicine, this product mainly has good antibacterial effect against Trichophyton, Microspores, and Epidermophyton fungi. However, it has no anti-bacterial effect on Candida, Cryptococcus, Histoplasma, Sporothrix, Blastomyces, and Coccidioides and so on. Mechanism of action of is drug is through interfering with the biosynthesis of nucleic acids of fungal and further inhibiting of its growth.

In agriculture, this product has good inhibitory effect on the Ascomycetes, Basidiomycetes, Deuteromycetes and some kinds of algae. However, it is not effective in treating oomycetes whose cell wall containing no chitin content. After spraying melons and other crops, it can be transferred into the branch, leaves and fruits through inner absorption, the absorption of water via rrot, as well as transpiration effect, and further preventing the fungal diseases; according to the study of Brandeis et al. (1946), at a concentration as low as even 10 mg/L or 1 mg/L, griseofulvin can already can make the mycelium of Bctrytis allill be stout, deformed and exhibit spiral bending, also cause: large number of abnormal branching; the development retardation of germinated spores, and loss of apical dominance; thus it has uptake therapeutic effects on a variety of plant diseases, especially powdery mildew, gray mold diseases; Griseofulvin has a more prominent antibacterial activity than the bactericidal activity.

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