Clobetasol Propionate

Topical Corticosteroid Anti-inflammatory Raw Powders Clobetasol Propionate CAS 25122-46-7

 

Quick Details for Clobetasol Propionate

Product Name: Clobetasol propionate
Synonyms: 17-propionate;cgp9555;clobesol;pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-me;CLOBESTASOL PROPIONATE;CLOBETASOL-17-PROPIONATE;CLOBETASOLE PROPIONATE;CLOBETASOL PROPIONATE
CAS: 25122-46-7
MF: C25H32ClFO5
MW: 466.97
EINECS: 246-634-3
Product Categories: Organics;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Pharmaceutical intermediate;TORADOL;Hormone Drugs;Halogenated Heterocycles ,Pyrazines ,Pyrans
Melting point : 195.5-197℃
Storage temp.: -20°C Freezer
Chemical Properties : White Crystalline Powder
Usage : For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.
Usage Topical corticosteroid. Glucocorticoid; anti-inflammatory.

 

Clobetasol Propionate Descriptions

Clobetasol Propionate is a highly potent topical steroid.It has both local anti inflammatory and immunosuppressive activity.Clobetasol, as the Propionate salt, is only used topically on the skin and its effects are limited to the local anti-inflammatory activity.

Clobetasol propionate is a corticosteroid of the glucocorticoid class used to treat various skin disorders including eczema and psoriasis. It is also highly effective for contact dermatitis caused by exposure to poison ivy/oak. Clobetasol belongs to US Class I (Europe: class IV) of the corticosteroids, making it one of the most potent available. It comes in shampoo, mousse, ointment and emollient cream presentations. It has very high potency and typically should not be used with occlusive dressings, or for extended continuous use (beyond two weeks). It is also used to treat several autoimmune diseases including alopecia areata, vitiligo, lichen sclerosus, and lichen planus.

Clobetasol propionate is marketed and sold worldwide under numerous names including Clobex, Clob-x (Colombia),Clovate, Cormax (Watson, US), Pentasol (Colombia), Cosvate (India), Temovate (US), Dermovate (GlaxoSmithKline, Pakistan, Portugal, Israel), Olux, Tenovate, Dermatovate, Butavate, Movate, Novate, and Powercort.

 

Pharmacology toxicology

This product is rapid, the current clinical application of effective topical cortico steroids medicine effect of a strong. Has the strong capillary contraction, the anti-inflammatory effects of hydrocortisone for 112.5 times, 2.3 times of betamethasone sodium phosphate, 18.7 times fluocinolone. Systemic adverse reactions for 3 times fluocinolone, anhydrous sodium retention effect, have certain promote sodium, potassium excretion .

 

Clobetasol Propionate Use

1. Clobetasol propionate is a synthetic high topical glucocorticoid drugs. Has a strong anti-inflammatory, anti itching and capillary vascular contraction, the anti-inflammatory effects of hydrocortisone is about 112.5 times, 2.3 times of betamethasone sodium phosphate, 18.7 times fluocinolone. At the same time with inhibition of cell mitosis, can effectively penetrate into the skin stratum corneum.

2. External apply to chronic eczema, neurodermatitis, psoriasis and palmoplantar pustulosis, lichen planus, discoid lupus erythematosus, glucocorticoid, topical treatment of pruritic effective and non infectious inflammatory skin disease.

3. Has the inhibitory effects of anti-inflammatory, anti allergic, anti proliferation, immune.Can compound products: ketoconazole. vitamin A acid cream and liniment.

 

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