Levobupivacaine Hydrochloride

Levobupivacaine Hydrochloride Local Anesthetic Powder CAS 27262-48-2

 

Quick Details for Levobupivacaine Hydrochloride

Product name : Levobupivacaine Hydrochloride
Synonyms: TIMTEC-BB SBB001337;(S)-(-)-BUPIVACAINE HCL;(S)-(-)-BUPIVACAINE HYDROCHLORIDE;(S)-(-)-1-N-BUTYL-2′,6′-DIMETHYL-2-PIPERIDINCARBOXANILID HYDROCHLORIDE;(S)-(-)-1-BUTYL-2-(2,6-XYLYLCARBAMOYL)-PIPERIDINE HYDROCHLORIDE;s-(-)-1-butyl-2′,6′-pipecoloxylidide hydrochloride;(s)-1-butyl-2’,6’-piperidinecarboxamidemonohydrochloride;(s)-1-butyl-n-(2,6-dimethylphenyl)-2-piperidinecarboxamidemonohydrochloride
CAS: 27262-48-2
MF: C18H29ClN2O
MW: 324.89
Product Categories: Pharmaceutical Raw Materials;Active Pharmaceutical Ingredients
Mol File: 27262-48-2.mol
mp 254 °C (dec.)(lit.)
alpha -12.5 º (c=2, water)
Chemical Properties : White crystalline powder
Usage : Local anaesthetic drug .

 

Levobupivacaine Hydrochloride Description

Levobupivacaine Hydrochloride is the hydrochloride salt of levobupivacaine, an amide derivative with anesthetic property.

Levobupivacaine reversibly binds voltage-gated sodium channels to modulate ionic flux and prevent the initiation and transmission of nerve impulses (stabilizing neuronal membrane), thereby resulting in analgesia and anesthesia. In comparison with racemic bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action.

Levobupivacaine is a local anaesthetic drug belonging to the amino amide group. It is the S-enantiomer of bupivacaine. Levobupivacaine hydrochloride is commonly marketed by AbbVie under the trade name Chirocaine.

 

Levobupivacaine Hydrochloride Clinical use

Compared to bupivacaine, levobupivacaine is associated with less vasodilation and has a longer duration of action. It is approximately 13 percent less potent (by molarity) than racemic bupivacaine and has a longer motor block onset time.

 

Levobupivacaine Hydrochloride Indications

Levobupivacaine is indicated for local anaesthesia including infiltration, nerve block, ophthalmic, epidural and intrathecal anaesthesia in adults; and infiltration analgesia in children.

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