Articaine Hydrochloride Epinephrine 23964-57-0 Articaine HCL Local Anesthetic
Quick Details of Articaine hydrochloride
Name: Articaine hydrochloride
CAS No.: 23964-57-0
Molecular Weight: 320.84
Synonyms: Articaine HCL;2-Thiophenecarboxylicacid, 4-methyl-3-[2-(propylamino)propionamido]-, methyl ester,monohydrochloride (8CI);2-Thiophenecarboxylic acid,4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-, methyl ester,monohydrochloride (9CI);Carticain;Carticainechlorhydrate;Carticaine hydrochloride;Methyl4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylatehydrochloride;Septanest;Ubistesine;Ultacain;Ultracain;Ultracaine;
Boiling Point: 440.6 °C at 760 mmHg
Flash Point: 220.3 °C
Appearance: white powder
Usage : local anesthetic(Oral use) .
Articaine hydrochloride Description
This drug was first synthesized by Rusching in 1969,and brought to the market in Germany by Hoechst AG, a life-sciences German company, under the brand name Ultracain. This drug was originally referred to as “carticaine” until 1984.
In 1983 it was brought into the North American market, to Canada, under the name Ultracaine for dental use, manufactured in Germany and distributed byHoechst-Marion-Roussel. This brand is currently manufactured in Germany bySanofi-Aventis and distributed in North America by Hansamed Limited (since 1999). After Ultracaine’s patent protection expired, new generic versions arrived to the Canadian market: (in order of appearance) Septanest (Septodont), Astracaine, (originally by AstraZeneca and now a Dentsplyproduct), Zorcaine (Carestream Health/Kodak) and Orabloc (Pierrel).
It was approved by the FDA in April 2000, and became available in the United States of America two months later under the brand name Septocaine, ananesthetic/vasoconstrictor combination with Epinephrine 1:100,000 (trade nameSeptodont). Zorcaine became available there a few years later, also. Articadent (Dentsply) became available in the United States in October 2010. The three brands currently available in the United States are all manufactured for these companies by Novocol Pharmaceuticals Inc. (Canada). Ubistesin and Ubistesin Forte (3M ESPE) are also widely used in the United States and Europe. Orabloc (Pierrel) is aseptically manufactured and was approved by the FDA in 2010, became available in Canada in 2011, and in Europe from 2013.
Articaine hydrochloride Application
Articaine is a local anaesthetic that has been approved overseas for several years.Like other amide anaesthetics, articaine blocks nerve conduction when it is infiltrated around a nerve.This action is prolonged by combining the drug with a vasoconstrictor .
The combination of articaine and adrenaline can be used for local or regional anaesthesia for dental procedures.