GHRP-2

Muscle Gaining and Anti Aging Pharmaceutical Polypeptide GHRP-2 158861-67-7 Growth Hormone

 

Quick Details for GHRP-2

GHRP-2 (Pralmorelin)
Alias: GHRP-2 Acetate; (DES-ALA3)-GROWTH E-RELEASING PEPTIDE-2
CAS: 158861-67-7
Molecular Formula : C45H55N9O6
Molecular Weight : 817.97
Purity : 99.55%
Appearance : White Lyophilized powder
Single Impurity (HPLC) : 1.0%max
Amino Acid Composition : ±10% of theoretical
Peptide Content (N%) : ≥80.0%
Water Content(Karl Fischer) : ≤6.0%
Acetate Content (HPIC) : ≤12.0%
MS(ESI) : Consistent
Mass Balance : 95.0~105.0%
Storage : Lyophilized GHRP-2 is stable at room temperature for 90 days,however it should be stored in a freezer below -8C for any extended period of time. After reconstituting GHRP-2 should be refrigerated at temperatures not to exceed 36 F.
Specification : 10mg/vial*10vial/kit,5mg/vial*10vial/kit

 

GHRP-2 Description

GHRP-2 is short for Growth Hormone Releasing Peptide 2, which basically refers to an hgH secretagogue, according to some research studies on rats, it can effectively increase the amount of natural secretion of hgH in the test subjects body and secrete it while stimulating the pituitary gland at the same time. Since the test subjects body will end up producing more growth hormones this way, fat will be reduced while lean muscle mass is increased. Along with this, IGF-1 levels will increase, as well, along with the different hypothalamus functions .

GHRP – 2 is a true hGH secretagogue. Which means it stimulates the body’s own secretion of hGH as explained in the study below. Human Growth hormone has been shown in studies to promote lean body mass and reduce adiposity (fat). ‘The group compared ITT to stimulation with GH releasing peptide 2 (GHRP-2). The synthetic hexapeptide, also named pralmorelin, is derived from a metenkephalin peptide. It is the most potent of the family of synthetic GH stimuli known in humans and acts via the endogenous ghrelin receptor (12). As these receptors have been identified both in the hypothalamus and the pituitary, GHRP-2 action may not be restricted to the pituitary.It has been reported that growth hormone (GH)-releasing peptide-2 (GHRP-2), a ghrelin receptor agonist, has an anti-inflammatory effect .

 

GHRP-2 Application

Ghrelin not only to promote the release of growth, but also has other biological effects, such as mediation feeding and energy metabolism, cardiovascular function, control gastrointestinal function and inhibition of tumor cell proliferation and so on. Recent studies have shown that serum ghrelin concentration was positively correlated with BMD, so ghrelin may be involved in the metabolism of bone tissue, affecting the function of osteoblasts.

GHRP-2 is a synthetic ghrelin analogue. Like ghrelin, it stimulates release of endogenous from soma to tropes in the anterior pituitary; also like ghrelin, it is synergistic with endogenous releasing-hormone (GHRH) as well as with synthetic GHRH analogues such as Sermorelin or GRF(1-29). Whereas GHRP-2 and other ghrelin analogues increase the number of soma to tropes involved in the GH pulse by inhibiting somatostatin, GHRH increases the pulse amplitude per pituitary cell or soma to trope by other means. Unlike ghrelin, GHRP-2 is synergistic with GHRH due to secondary actions on hypothalamic neurons. The quantity of GH released by a living mammal to which GHRP-2 and GHRH are administered exceeds the combined release of each compound when measured when taken alone.

 

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